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TranscriptomicsLineage-specific functions of TET1 in the post-implantation mouse embryo
The TET dioxygenases erase mediate DNA dedemethylation in pre-implantation embryos and in primordial germ cells, yet limited studies address their contribution to the global gain of DNA methylation following implantation. Here, we show that Tet1 is expressed and non-redundantly contributes to 5-hydr...
ORGANISM(S): Mus musculus 
2017-05-15 | E-GEOD-71744 | biostudies-arrayexpress
GenomicsEpigenetic regulation and transcriptional repression by Tet1 in the early post-implantation mouse embryo: Methylation data.
The mammalian TET dioxygenases contribute to global waves of DNA demethylation in the zygote and in primordial germ cells, but their involvement during de novo DNA methylation at peri/post-implantation development is unknown. Here, we show novel physiological functions of Tet1 in the pre-primitive s...
ORGANISM(S): Mus musculus 
2017-05-15 | E-MTAB-4581 | biostudies-arrayexpress
GenomicsEpigenetic regulation and transcriptional repression by Tet1 in the early post-implantation mouse embryo: ChIP seq
The mammalian TET dioxygenases contribute to global waves of DNA demethylation in the zygote and in primordial germ cells, but their involvement during de novo DNA methylation at peri/post-implantation development is unknown. Here, we show novel physiological functions of Tet1 in the pre-primitive s...
ORGANISM(S): Mus musculus 
2017-05-15 | E-MTAB-5562 | biostudies-arrayexpress
TranscriptomicsLineage-specific functions of TET1 in the post-implantation mouse embryo.: RNA-Seq of in vitro converted primed epiblast-like cells
The mammalian TET dioxygenases contribute to global waves of DNA demethylation in the zygote and in primordial germ cells, but their involvement during de novo DNA methylation at peri/post-implantation development is unknown. Here, we investigate the role
ORGANISM(S): Mus musculus 
2017-05-15 | E-MTAB-4578 | biostudies-arrayexpress
TranscriptomicsIn vitro differentiation of rat multipotent adult porgenitor cells to smooth muscle like cells
The aim of the study was to characterize the molecular mechanism involved in TGF-M-CM-^_ mediated smooth muscle formation in vitro. We employed rat bone marrow derived Oct4 expressing clones of multipotent adult progenitor cells (rMAPC). We subjected these cells to differentiation towards smooth mus...
ORGANISM(S): Rattus norvegicus 
2012-10-09 | E-GEOD-32990 | biostudies-arrayexpress
TranscriptomicsMAPC culture condition supports the derivation of cells with nascent hypoblast features from bone marrow and blastocysts
Rat Extraembryonic Endoderm Precursor (XEN-P) cells resemble the nascent hypoblast of the blastocyst. Here we show that rat Multipotent Adult Progenitor Cell (rMAPC) lines derived from bone marrow (BM) exhibit salient nascent hypoblast characteristics. We could not identify cells with hypoblast feat...
ORGANISM(S): Rattus norvegicus 
2012-07-16 | E-GEOD-29114 | biostudies-arrayexpress
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