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TranscriptomicsIGR_Itzykson_CMML
Genomic studies in chronic myeloid malignancies, including myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS) and MPN/MDS, have identified common mutations in genes encoding signaling, epigenetic, transcription and splicing factors. Analysis of 18 of these genes in a cohort of 224 c...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-MTAB-1044 | biostudies-arrayexpress
GenomicsGustave Roussy CMML Collection DAC
Data Access Committee EGAC00001000342
EGAC00001000342 | EGA
ProteomicsCalprotectin promotes anemia of inflammation in healthy and pathological conditions
Elevated circulating levels of calprotectin (CAL), the S100A8/A9 heterodimer, are biomarkers of severe systemic inflammation. Here, we investigate the effects of CAL on early human hematopoiesis. CAL demonstrates limited impact on gene expression in stem and progenitor cells, in contrast with interl...
ORGANISM(S): Homo sapiens (Human) 
2024-11-20 | PXD057999 | Pride
Calprotectin Erythroblaste 
TranscriptomicsEffect of T0901317, AM580 or T0901317+AM580 on monocyte gene expression
The aim of this study was to investigate the effect of T0901317 LXR agonist on Retinoic Acid Receptor (RAR) family gene expression. T0901317 alone increase RARalpha gene expression in monocytes and the effects of the co treatment of the cells with T0901317 and a specific RARalpha agonist (AM580) wer...
ORGANISM(S): Homo sapiens 
2010-04-08 | E-GEOD-13407 | biostudies-arrayexpress
GenomicsDAC CMML
Data Access Committee EGAC00001002011
EGAC00001002011 | EGA
Genomicsena-DATASET-GR-05-12-2015-13:51:06:366-72 - samples
In this dataset are the data from : - 17 patients studied by WGS - 49 patients studied by WES - 9 (/49) patients studied by RNASeq at 2 time points - the same 9 patients studied by ERRBS at 2 time points
EGAD00001001853 | EGA
GenomicsCMML Collection of WES, WGS, RNA-Seq and ERRBS data
We first performed a comprehensive analysis of the genome of 66 chronic myelomonocytic leukemia cases using whole exome (N=49) or whole genome (N=17) sequencing for paired leukemic-control DNA. Then, we realized serial analysis of whole exome sequence in 17 cases, completed with serial RNA sequencin...
EGAS00001001264 | EGA
GenomicsChIP-seq of EGR1 in human primary unstimulated monocytes and in unstimulated human monocytes from three CMML patients
Identification of EGR1 chromatin localization in human primary monocytes (2 donors), in human primary monocytes from 2 CMML patients with TET2 truncating mutations (high VAF) and in human primary monocytes from 1 CMML patients with TET2 truncating mutations with low VAF.
ORGANISM(S): Homo sapiens 
2021-11-15 | E-MTAB-11132 | biostudies-arrayexpress
GenomicsTET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially for the TET2 and TET3 proteins, remains limite...
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-36620 | biostudies-arrayexpress
TranscriptomicsGermline duplication of ATG2B and GSKIP predisposes to familial essential thrombocythemia rapidly progressing to acute leukemia
No major predisposing gene for familial myeloproliferative neoplasms (MPN) has been identified. Here, we demonstrate that the autosomal dominant transmission of a 700 kb duplication in four geographically-related families predisposes to MPN rapidly progressing to acute leukemia. Using induced plurip...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-67938 | biostudies-arrayexpress
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