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ProteomicsTRAF6 integrates innate immune signals to regulate glucose homeostasis via control of mitophagy
Elevated or chronic innate immune activation plays a role in the progression of metabolic diseases such as diabetes, yet the influence of innate immune signaling on pancreatic β-cells is not well characterized. Here we report that TRAF6, an E3 ubiquitin ligase downstream of TLR signaling, maintains ...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-21 | PXD063412 | Pride
Mitochondria Innate immunity Beta cells Metabolic stress 
ProteomicsLONP1 regulation of mitochondrial protein folding provides insight into beta cell failure in type 2 diabetes
Protein misfolding is a contributor to the development of type 2 diabetes (T2D), but it is unknown whether impaired proteostasis in T2D is generalized or has special features. Here, we report a robust accumulation of misfolded proteins within the mitochondria of human pancreatic islets from patients...
ORGANISM(S): Homo sapiens (Human) 
2025-06-05 | PXD060404 | Pride
Diabetes  apoptosis  mitochondrial protein folding  lonp1 
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