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ProteomicsProtamine characterization by top-down proteomics: Boosting proteoform identification with DBSCAN
Protamines replace histones as the main nuclear protein in sperm cells having a crucial role in compacting the paternal genome. Human spermatozoa contain the protamine 1 (P1) and the family of protamine 2 (P2) proteins. Alterations in protamine PTMs or on the P1/P2 ratio could be associated with mal...
ORGANISM(S): Homo sapiens (Human) 
2021-05-13 | PXD024405 | Pride
Male infertility  sperm  protamine  lc-ms/ms  top down proteomics  proteoform  post-translational modifications  bioinformatics  dbscan. 
ProteomicsSILAC-Based Proteomics of Primary Human Kidney Cells treated with Sex Hormones.
Male sex predispose to many kidney diseases. Considering that androgens exert deleterious effects in a variety of cell types within kidney, we hypothesized that dihydrotestosterone (DHT) would impair the biology of the renal tubular cell by inducing changes in the proteome. We employed stable isotop...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080854 | MassIVE
UnknownCohort Profile: The Epidemiology of Chronic Diseases and Multimorbidity. The EpiChron Cohort Study.
Not available
S-EPMC5913592 | biostudies-literature
TranscriptomicsTonsil Atlas FASTQ files
This repository contains all the FASTQ files for the five data modalities (scRNA-seq, scATAC-seq, Multiome, CITE-seq+scVDJ-seq, and spatial transcriptomics) used in the article \\"An Atlas of Cells in The Human Tonsil,\\" published in Immunity in 2024. Inspired by the TCGA barcodes, we have named ea...
ORGANISM(S): Homo sapiens 
2024-05-02 | E-MTAB-13687 | biostudies-arrayexpress
UnknownEffectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy: study protocol of a cluster randomized clinical trial (Multi-PAP project).
Not available
S-EPMC5406997 | biostudies-literature
UnknownHow to Improve Healthcare for Patients with Multimorbidity and Polypharmacy in Primary Care: A Pragmatic Cluster-Randomized Clinical Trial of the MULTIPAP Intervention.
Not available
S-EPMC9144280 | biostudies-literature
UnknownEffectiveness of the MULTIPAP Plus intervention in youngest-old patients with multimorbidity and polypharmacy aimed at improving prescribing practices in primary care: study protocol of a cluster randomized trial.
Not available
S-EPMC9178530 | biostudies-literature
UnknownExtended pharmacological thromboprophylaxis and clinically relevant venous thromboembolism after major abdominal and pelvic surgery: international, prospective, propensity score-weighted cohort study.
Not available
S-EPMC11894929 | biostudies-literature
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