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ProteomicsSoluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation
The liver plays an important role in cardiovascular disease by amplifying systemic inflammation, while the underlying mechanisms remain to be defined. Soluble epoxide hydrolase (sEH) is a pro-inflammatory enzyme and pharmacological inhibition of sEH was shown to protect against various inflammatory ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-07 | PXD073197 | Pride
Angiotensin ii Calcium chloride Liver Soluble epoxide hydrolase Abdominal aortic aneurysm 
GenomicsSoluble epoxide hydrolase inhibition confers neuroprotective and anti-inflammatory effect in a tauopathy mouse model
Soluble epoxide hydrolase inhibition confers neuroprotective and anti-inflammatory effect in a tauopathy mouse model
PRJNA1136532 | ENA
GenomicsSoluble Epoxide Hydrolase Inhibition Attenuated Chronic Alcohol-Associated Liver Injury and Altered the Hepatic Proteome in Mice
Effect of soluble epoxide hydrolase inhibition on alcohol-associated liver disease
PRJEB83110 | ENA
TranscriptomicsSoluble epoxide hydrolase inhibition confers neuroprotective and anti-inflammatory effect in a tauopathy mouse model
Inhibition of soluble epoxide hydrolase (sEH) has been shown to suppress neuroinflammation through stabilizing epoxy fatty acids. Here we examined the role of sEH inhibitor TPPU in PS19 tauopathy mouse model by treating the 6-month-old wild-type and PS19 mice with vehicle or TPPU via drinking water ...
ORGANISM(S): Mus musculus 
2025-04-30 | GSE272373 | GEO
GenomicsA regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-b signaling
A regulatory loop involving the cytochrome P450-soluble epoxide hydrolase axis and TGF-b signaling
PRJNA1143571 | ENA
UnknownZinc-mediated Inhibition of Soluble Epoxide Hydrolase Promotes Pulmonary Hypertension.
Not available
S-EPMC12499926 | biostudies-literature
GenomicsHepatocyte-Specific Transcriptional Responses to Liver-Targeted Delivery of a Soluble Epoxide Hydrolase Inhibitor in a Mouse Model of Alcohol-Associated Liver Disease
Liver-Specific Delivery of a soluble epoxide hydrolase inhibitor in mouse model of ALD
PRJEB96044 | ENA
GenomicsMethylation profiling of C.elegans to identify CEH-60/PBX binding sites
CEH-60 binding profile by comparison of DNA methylation of a C. elegans strain expression ceh-60::dam to a control strain expressing gfp::dam. Sequencing libraries prepared using NEBNext Singleplex oligos for Illumina®. Data analysis performed with GeneDamIDseq (Sharma, Ritler, and Meister 2016).
ORGANISM(S): Caenorhabditis elegans 
2020-11-16 | E-MTAB-9539 | biostudies-arrayexpress
UnknownDiscovery of Novel Soluble Epoxide Hydrolase Inhibitors as Potent Vasodilators.
Not available
S-EPMC6168526 | biostudies-literature
UnknownInhibition of soluble epoxide hydrolase reduces paraquat neurotoxicity in rodents.
Not available
S-EPMC9992278 | biostudies-literature
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