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TranscriptomicsTranscription profiling of mouse at ages P4 and P60 in sciatic nerve of wild type and with peripheral neuropathies to study disease mechanisms in peripheral neuropathies due to altered Pmp22 gene dosage or a Pmp22 point mutation
We compared gene expression at ages P4 and P60 in sciatic nerve of wild type mice and mice with peripheral neuropathies caused by altered Pmp22 gene dosage (homozygous knockout or transgene) or a point mutation (Trembler).
ORGANISM(S): Mus musculus 
2007-11-03 | E-GEOD-1947 | biostudies-arrayexpress
TranscriptomicsExpression data from E11.5 mouse branchial arch 1 (BA1) - comparison between Ezh2lox/lox and Wnt1Cre Ezh2lox/lox embryos
Conditional ablation of Ezh2 in the neural crest lineage results in loss of the neural crest-derived mesenchymal derivatives. In this data sheet we determine gene expression analysis in Ezh2lox/lox and Wnt1Cre Ezh2lox/lox in E11.5 mouse BA1 cells. Conditional ablation of Ezh2 in the neural crest lin...
ORGANISM(S): Mus musculus 
2013-11-09 | E-GEOD-52220 | biostudies-arrayexpress
TranscriptomicsLoss of Ezh2 promotes a midbrain-to-forebrain identity switch by direct gene derepression and Wnt-dependent regulation
Background: Precise spatiotemporal control of gene expression is essential for the establishment of correct cell numbers and identities during brain development. This process involves epigenetic control mechanisms, such as those mediated by the polycomb group protein Ezh2 that catalyzes trimethylat...
ORGANISM(S): Mus musculus 
2015-11-09 | E-GEOD-74538 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of early development of neural crest stem cells and developing Schwann cells, from embryonic day 9.5 to postnatal day 0.
Time course of early development of peripheral nerve, from embryonic day 9.5 to postnatal day 0. Origin of samples: mouse embryos expressing green fluorescent protein (GFP) in neural crest stem cells and later glial cells under the control of the proteolipid protein gene (Plp) promoter. At E9.5 the ...
ORGANISM(S): Mus musculus 
2007-12-13 | E-GEOD-972 | biostudies-arrayexpress
TranscriptomicsThe role of SOX10 in human melanoma
We have shown that Sox10 plays a crucial role in the initiation and maintenance of giant congenital nevi and melanoma in a mouse model of melanoma.To dissect the molecular mechanisms and analyze the role of SOX10 in the maintenance of human melanoma, we have performed microarray study. Human melan...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-37059 | biostudies-arrayexpress
TranscriptomicsWnt/b-catenin signaling regulates sequential fate decisions of murine cortical precursor cells
In order to compare expression changes upon Wnt/b-catenin signaling inactivation in the forebrain of mouse embryos, we have isolated dorso-medial pallium from E11.5 mutant and control embryos and performed microarray analysis. Dorso-medial pallium from E11.5 control and mutant embryos was dissected ...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-70134 | biostudies-arrayexpress
TranscriptomicsMesenchymal stem cells and neural crest stem cells from adult bone marrow: characterization of their surprising similarities and differences
The generation of neuronal cells from stem cells obtained from adult bone marrow is of significant clinical interest in order to design new cell therapy protocols for several neurological disorders. The recent identification in adult bone marrow of stem cells derived from the neural crests (NCSCs) ...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-30419 | biostudies-arrayexpress
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