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ProteomicsDrug-driven phenotypic convergence supports rational treatment strategies of chronic infections
Chronic Pseudomonas aeruginosa infections evades antibiotic therapy and are associated with mortality in cystic fibrosis (CF) patients. We find that in vitro resistance evolution of P.aeruginosa towards clinically relevant antibiotics leads to phenotypic convergence towards distinct states. These st...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2018-10-23 | PXD007972 | Pride
Collateral sensitivity Cystic fibrosis Nfxb Chronic infections Phenotypic convergence Drug resistance Pseudomonas aeruginosa 
MetabolomicsAntibiotics create a shift from mutualism to competition in human gut communities with a longer-lasting impact on fungi than bacteria

Background

Antibiotic treatment has a well-established detrimental effect on the gut bacterial composition, but effects on the fungal community are less clear. Bacteria in the lumen of the gastrointestinal tract may limit fungal colonization and invasion. Antibiotic drugs t...

2020-09-28 | MTBLS1846 | MetaboLights
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