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TranscriptomicsRNA-Seq after knockdown of SON in human embryonic stem cells
Human embryonic stem cells (hESCs) harbor the ability to undergo lineage-specific differentiation into clinically relevant cell types. Transcription factors and epigenetic modifiers are known to play important roles in the maintenance of pluripotency of hESCs. However, little is known about regulati...
ORGANISM(S): Homo sapiens 
2013-08-29 | E-MTAB-1687 | biostudies-arrayexpress
TranscriptomicsDeep transcriptome analysis of mouse embryonic fibroblast following simultaneous overexpression of Stella, Oct4 and Nanos2 (SON)
We constructed a polycistronic lentiviral vector to overexpress 3 germ cell specific genes (Stella, Oct4 and Nanos2) in mouse embryonic fibroblast (MEFs) and evaluated the transcriptome portrait in partially reprogrammed cells.We sequenced RNA samples from bulk cell population of two biological dup...
ORGANISM(S): Mus musculus 
2016-07-30 | E-GEOD-77351 | biostudies-arrayexpress
TranscriptomicsSon Maintains Accurate Splicing of Pre-mRNAs Encoding Chromatin Modifiers
Exon and expression analysis of HeLa cells after knockdown of SON Serine-arginine-rich (SR) proteins play a key role in alternative pre-mRNA splicing in eukaryotes. Our laboratory recently showed that a large SR protein called Son has unique repeat motifs that are essential for maintaining the subnu...
ORGANISM(S): Homo sapiens 
2011-12-22 | E-GEOD-28672 | biostudies-arrayexpress
TranscriptomicsSSH-PCR dehydrated supraoptic nucleus
The magnocellullar neurons (MCNs) of the supraoptic nucleus (SON) of the hypothalamus are the principle source of the neuropeptide hormone vasopressin (VP), which has a crucial role in osmoregulation. Physiological activation of the SON by dehydration results is a massive release of VP from stores i...
ORGANISM(S): Rattus norvegicus 
2010-06-30 | E-GEOD-3132 | biostudies-arrayexpress
TranscriptomicsExpression data from HeLa cells transiently transfected with control siRNA or SON siRNA
SON is a large Ser/Arg (SR)-related protein localized in nuclear speckles. SON siRNA causes defects in mitotic progression and genome instability. We used microarrays to detail the pattern of gene expression after SON knockdown. HeLa cells were grown in 100 mm dishes and transfected with negative co...
ORGANISM(S): Homo sapiens 
2011-04-01 | E-GEOD-26888 | biostudies-arrayexpress
TranscriptomicsTranscriptomic analysis of the osmotic and reproductive remodelling of the female rat supraoptic nucleus
The supraoptic nucleus (SON) of the hypothalamus is an important integrative brain structure that co-ordinates responses to perturbations in water balance and regulates maternal physiology through the release of the neuropeptide hormones vasopressin and oxytocin into the circulation. Both dehydratio...
ORGANISM(S): Rattus norvegicus 
2011-12-29 | E-GEOD-30733 | biostudies-arrayexpress
MetabolomicsA mitochondrial NADPH-cholesterol axis regulates extracellular vesicle biogenesis to support hematopoietic stem cell fate

Mitochondrial fatty acid oxidation (FAO) is essential for hematopoietic stem cell (HSC) self-renewal; however, the mechanism by which mitochondrial metabolism controls HSC fate remains unknown. Here, we show that within the hematopoietic lineage, HSCs have the largest mitochondrial NADPH pools, w...

2025-07-07 | MTBLS6401 | MetaboLights
GenomicsA Novel Dominant Negative Variant of IRF8 in a Mother and Son: Clinical, Phenotypic and Biological Characteristics
A Novel Dominant Negative Variant of IRF8 in a Mother and Son: Clinical, Phenotypic and Biological Characteristics
PRJNA1096954 | ENA
TranscriptomicsTranscription profiling of PVN/SON region of mouse brain after saline treatment to identify differentially expressed miRNAs
Identifying of differentially expressed miRNAs in PVN/SON region of the brain after saline treatment.
ORGANISM(S): Mus musculus 
2006-10-02 | E-MEXP-786 | biostudies-arrayexpress
TranscriptomicsHypothalamic transcriptome plasticity in two rodent species reveals divergent differential gene expression but conserved pathways
We have addressed the question of how different rodent species cope with the life-threatening homeostatic challenge of dehydration at the level of transcriptome modulation in the supraoptic nucleus (SON), a specialised hypothalamic neurosecretory apparatus responsible for the production of the antid...
ORGANISM(S): Mus musculus 
2010-11-29 | E-GEOD-25574 | biostudies-arrayexpress
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