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TranscriptomicsTranscription profiling of human CD133-positive G0 and G1 human ubmbilical vein cells
To identify regulators of human HSC fate, we transcriptionally profiled quiescent primitive cord blood (CB) CD133+ G0 cells enriched for long term culture initiating cell (LTC-IC) activity. CD133+ G0 cells were sorted by cell cycle status using combined DNA and RNA staining; less immature CD133+G1 c...
ORGANISM(S): Homo sapiens 
2008-03-06 | E-MEXP-1412 | biostudies-arrayexpress
TranscriptomicsIdentification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem- and progenitor cells
To discover novel growth factors for hematopoietic stem- and progenitor cells (HSPCs), we have assessed cytokine responses of cord blood (CB)-derived CD34+ cells in a high-content growth factor screen. We identify the immunoregulatory chemokine (C-C motif) ligand 28 (CCL28) as a novel growth factor ...
ORGANISM(S): Homo sapiens 
2013-06-03 | E-GEOD-45136 | biostudies-arrayexpress
TranscriptomicsGenome-wide identification of SCL/Tal1‰€™s functional targets; insights into its mechanisms of action in primary erythroid cells
Coordination of cellular processes through the establishment of tissue-specific gene expression programmes is essential for lineage maturation. The basic helix-loop-helix haemopoietic transcriptional regulator SCL/Tal1 is required for terminal differentiation of red blood cells. To gain insight into...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21877 | biostudies-arrayexpress
TranscriptomicsIntrinsic Protection From Leukemic Transformation at The Level of Hematopoietic Stem Cells
Genome wide RNA-seq from pGM and HSCs in response to expression of the MLL-ENL fusion gene Examination of mRNA abundance in two cell types with or without induction of the MLL-ENL fusion gene (following 48h of culture)
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-62734 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [TC]
An expression time course experiment to investigate gene expression changes during differentiation of multipotential cells over two lineages using the model cell line FDCPmix differentiating towards erytroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, d...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49987 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [HP]
FDCPmix cells were infected with Gata, Pu1 shRNAs and microarrayed 5 days after infecton as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relationships bet...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49989 | biostudies-arrayexpress
GenomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [ChIP-seq].
We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. We combined global ChIPSeq of GATA1, GATA2 and PU.1 with expression profiling during differe...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-50406 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [ER]
FDCPmix cells were infected with Gata1 and Pu1 ER fusion proteins and microarrayed after induction to reveal genes regulated by each factor as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to e...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49990 | biostudies-arrayexpress
TranscriptomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors [PC]
Primary hematopoietic cells from mouse bone marrow were sorted and hybridised expression microarrays as part of a study investigating the differentiation of a multipotential cell-line to erthroid and myeloid fates. We used the paradigmatic 'GATA-PU.1 axis’ to explore, at systems-level, dynamic relat...
ORGANISM(S): Mus musculus 
2013-10-17 | E-GEOD-49988 | biostudies-arrayexpress
GenomicsDynamic analysis of gene expression and genome wide transcription factor binding during lineage-specification of multipotent progenitors
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-10-15 | E-GEOD-49991 | biostudies-arrayexpress
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