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GenomicsGenome-wide maps of cytosine methylation, cytosine hydroxylmethylation and small non coding RNAs in mouse ES cells and upon guided differentiation to mesoendoderm cells
Genome-wide maps of cytosine methylation, cytosine hydroxylmethylation and small non coding RNAs in mouse ES cells and upon guided differentiation to mesoendoderm cells. Mouse embryonic stem cells (E14) were guided differentiated into mesoendoderm lineages by activin-A induction. cells in three time...
ORGANISM(S): Mus musculus 
2012-09-22 | E-GEOD-38596 | biostudies-arrayexpress
GenomicsGenome-wide analysis of K3K27ac, H2AZ and methylation data in mouse embryonic stem cells
We generated two types 5-methylcytosine (5-mC) data in E14 mouse embryonic stem cells, using methylated DNA immunoprecipitation followed by sequencing (MeDIP-seq) and DNA digestion by methyl-sensitive restriction enzymes followed by sequencing (MRE-seq). Examination of 2 histone modifications and me...
ORGANISM(S): Mus musculus 
2014-01-09 | E-GEOD-34953 | biostudies-arrayexpress
TranscriptomicsTet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
Recurrent somatic mutations in TET2 and in other genes that regulate the epigenetic state have been identified in patients with myeloid malignancies and in other cancers. However, the in vivo effects of Tet2 loss have not been delineated. We report here that Tet2 loss leads to increased stem-cell...
ORGANISM(S): Mus musculus 
2011-07-01 | E-GEOD-27816 | biostudies-arrayexpress
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