Sort   by:  
 Page size 
TranscriptomicsTranscription profiling of mouse mammary tumors from K14-cre; ApcCKO/+ vs control mammary glands
Many components of Wnt/β-catenin signaling pathway also play critical roles in mammary tumor development. To study the role of Apc in mammary tumorigensis, we introduced conditional Apc mutations specifically into two different mammary epithelial populations using K14-Cre (progenitor) and WAP-cre ...
ORGANISM(S): Mus musculus 
2009-02-21 | E-GEOD-14753 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse Rb1 deficient Apc1638N cecal tumors vs duodenal tumors
To examine the role of Rb1 in gastrointestinal (GI) tumors we generated mice with an Apc1638N allele, Rbtm2brn floxed alleles, and a villlin-cre transgene (RBVCA). These mice had reduced median survival due to an increase in tumor incidence and multiplicity in the cecum and the proximal colon; they ...
ORGANISM(S): Mus musculus 
2008-11-13 | E-GEOD-13298 | biostudies-arrayexpress
TranscriptomicsInhibiting tankyrases sensitizes KRAS mutant cancer cells to MEK inhibitors by FGFR2 feedback signaling
Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis and mitosis, offering attractive targets for anti-cancer treatment. Using unbiased combination screening in a large panel of cancer cell lines, we have identified a strong synergy between TNKS and MEK inhibitors in KRAS mutant cance...
ORGANISM(S): Homo sapiens 
2014-03-06 | E-GEOD-55624 | biostudies-arrayexpress
Sort   by:  
 Page size