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TranscriptomicsTranscription profiling by array of lymphoblastic cells, fat and skin from twins
Gene expression was quantified in LCL, skin and fat derived from a subset of Twins UK (N=156 LCL, N=160 skin, N=166 fat) using Illuminas whole genome expression array (HumanHT-12 version 3). Cis eQTL analysis was performed in each tissue, following by multiple analyses assessing the tissue-specifici...
ORGANISM(S): Homo sapiens 
2011-02-03 | E-MTAB-522 | biostudies-arrayexpress
MetabolomicsRare and common genetic determinants of metabolic individuality and their effects on human health (EPIC-Norfolk study assays)

Garrod’s concept of “chemical individuality” has contributed to comprehension of the molecular origins of human diseases. Untargeted high-throughput metabolomic technologies provide an in-depth snapshot of human metabolism at scale. We studied the genetic architecture of the human plasma metabolo...

2022-09-09 | MTBLS833 | MetaboLights
GenomicsUK10K COHORT TWINSUK
The UK10K project proposes a series of complementary genetic approaches to find new low-frequency/rare variants contributing to disease phenotypes. These will be based on obtaining the genome-wide sequence of 4000 samples from the TwinsUK and ALSPAC cohorts (at 6x sequence coverage), and the exome ...
EGAS00001000108 | EGA
GenomicsWhole-genome low pass sequencing of 3,514 Sardinian individuals
The dataset includes the VCF files with the list of variants, and their frequency, found in 3,514 Sardinian individuals recruited from the SardiNIA longitudinal study (N=2090) and from a case-control study of autoimmune diseases in Sardinia (N=1424).
EGAS00001002212 | EGA
GenomicsUK10K The Department of Twin Research and Genetic Epidemiology (TwinsUK) Variants
The UK10K project proposes a series of complementary genetic approaches to find new low-frequency/rare variants contributing to disease phenotypes. These will be based on obtaining the genome-wide sequence of 4000 samples from the Department of Twin Research and Genetic Epidemiology (TwinsUK) and Av...
ORGANISM(S): Homo Sapiens 
2014-10-20 | PRJEB7218 | EVA
GenomicsUK10K Avon Longitudinal Study of Parents and Children (ALSPAC) Variants
The UK10K project proposes a series of complementary genetic approaches to find new low-frequency/rare variants contributing to disease phenotypes. These will be based on obtaining the genome-wide sequence of 4000 samples from the Department of Twin Research and Genetic Epidemiology (TwinsUK) and Av...
ORGANISM(S): Homo Sapiens 
2014-10-20 | PRJEB7217 | EVA
GenomicsA Population Genomics Study Using a Disease-Targeted Cell model: Integration of cis-eQTLs Discovered in Human Primary Osteoblasts with GWAS of Bone Phenotypes

The common genetic variants associated with complex traits typically lie in non-coding DNA and may alter gene regulation in a cell type-specific manner. Consequently, the choice of tissue or cell model in the dissection of disease associations is important. We carried out an expression quanti...

phs000225.v1.p1 | EGA
GenomicsDNA_Methylation_450K
BLUEPRINT DNA methylation profiles of monocytes, neutrophils and T cells from healthy donors
EGAD00010000850 | EGA
GenomicsWP8_DNA_Methylation_450K_UCL
BLUEPRINT DNA methylation profiles of monocytes, T cells and B cells in type 1 diabetes-discordant monozygotic twins
EGAD00010001025 | EGA
GenomicsBLUEPRINT EpiVar 450K DNA methylation profiles of naive CD4+ T-cells, monocytes & neutrophils
BLUEPRINT EpiVar 450K DNA methylation profiles of naive CD4+ T-cells, > monocytes & neutrophils
EGAS00001001456 | EGA
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