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UnknownThe HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes
HACE1 is a HECT family E3 ubiquitin-protein ligase with broad but incompletely understood tumor suppressor activity. Here we report a previously unrecognized link between HACE1 and signaling complexes containing mammalian target of rapamycin (mTOR). Specifically, HACE1 blocks mTORC1 and mTORC2 activ...
S-SCDT-10_15252-EMBR_202356815 | biostudies-other
UnknownDisruption of the ASTN2/TRIM32 locus at 9q33.1 is a risk factor in males for autism spectrum disorders, ADHD and other neurodevelopmental phenotypes.
Rare copy number variants (CNVs) disrupting ASTN2 or both ASTN2 and TRIM32 have been reported at 9q33.1 by genome-wide studies in a few individuals with neurodevelopmental disorders (NDDs). The vertebrate-specific astrotactins, ASTN2 and its paralog ASTN1, have key roles in glial-guided neuronal mig...
S-EPMC3990173 | biostudies-literature
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