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TranscriptomicsDeep sequencing of the small RNA transcriptome of blood leukocytes from Parkinson's disease patients prior to and following deep brain stimulation (DBS) and as compared with healthy control volunteers
We report the application of small RNA sequencing technology for high-throughput profiling of microRNA molecules (miRNAs) in blood leukocytes of Parkinson's Disease (PD) patients. Expression changes which may contribute to PD pathogenesis and reaction to treatment were identified in RNA preparations...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-GEOD-40915 | biostudies-arrayexpress
TranscriptomicsExpression data from advanced Parkinson's disease (PD) patients leukocytes - prior to and following deep brain stimulation (DBS) treatment in on and off stimulation conditions, and matched healthy control (HC) subjects
Sub-thalamic deep brain stimulation (DBS) reversibly modulates ParkinsonM-bM-^@M-^Ys disease (PD) motor symptoms, providing an unusual opportunity to compare leukocyte transcripts in the same subjects before and after neurosurgery and after disconnecting the stimulus (ON-and OFF-stimulus). Here, we ...
ORGANISM(S): Homo sapiens 
2012-01-09 | E-GEOD-23676 | biostudies-arrayexpress
TranscriptomicsWhole-transcriptome high-throughput RNA sequencing of blood leukocytes from Parkinson's disease human patients pre- and post-deep brain stimulation
The given data set is the first deep sequencing transcriptome-wide data set of human Parkinson's disease (PD) patients RNA. The data set was produced from blood leukocytes of PD patients, from the same patients following deep brain stimulation (DBS), and from matched healthy control volunteers. Post...
ORGANISM(S): Homo sapiens 
2014-07-16 | E-GEOD-42608 | biostudies-arrayexpress
TranscriptomicsHuman Splice Junction Arrays of Parkinson's Patients Leukocytes mRNA Pre- and Post-Deep Brain Stimulation
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide and the first involving motor symptoms. Deep brain stimulation (DBS) neurosurgery treatment through electrodes implanted to the subthalamic nucleus (STN) improves dramatically the debilitating motor symptoms of th...
ORGANISM(S): Homo sapiens 
2015-05-22 | E-GEOD-37591 | biostudies-arrayexpress
TranscriptomicsExpression data from naM-CM-/ve and MPTP-exposed cholinergic transgenic mice
PD is the second most common neurodegenerative disease worldwide with growing prevalence. MPTP is a neurotoxin which causes the appearance of Parkinson's disease (PD) pathology. The involvement of the cholinergic system in PD has been identified decades ago and anti-cholinergic drugs were upon the...
ORGANISM(S): Mus musculus 
2012-01-09 | E-GEOD-31458 | biostudies-arrayexpress
TranscriptomicsExpression data from non-demented controls (NDCs) and Alzheimer's disease (AD) patients
AD is the leading cause of dementia in the elderly. However, disease etiology is still practically unknown. To gain insight into the molecular mechanisms underlying this disease we used the Affymetrix exon arrays to profile the alternative splicing landscape of human entorhinal cortex samples from A...
ORGANISM(S): Homo sapiens 
2012-09-06 | E-GEOD-26972 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling in human macrophages under immunogenic treatments in vitro
MicroRNAs (miRs) contribute to both neuronal and immune cell fate, but their involvement in inter-tissue communication remained unexplored. The brain, via vagal secretion of acetylcholine (ACh), suppresses peripheral inflammation by intercepting cytokine production; therefore, we predicted that micr...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-19094 | biostudies-arrayexpress
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