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TranscriptomicsFactorial study for evaluating the effect of Affy platform and lab on gene expression measurements
Comparison of concordance in single and multi-gene genomic indices from data generated by two different laboratories (MD Anderson Cancer Center (MDA) and Jules Bordet Institute (JBI)) and on two different Affymetrix platforms (U113A and U133_Plus2). We used a 2x2 factorial study in which 16 clinica...
ORGANISM(S): Homo sapiens 
2010-08-13 | E-GEOD-17700 | biostudies-arrayexpress
UnknownPIK3CA mutations are associated with decreased benefit to neoadjuvant human epidermal growth factor receptor 2-targeted therapies in breast cancer.
Not available
S-EPMC5087318 | biostudies-literature
GenomicsDATA ACCESS COMMITTEE BCTL-IRIBHM
Data Access Committee EGAC00001000120
EGAC00001000120 | EGA
TranscriptomicsEndocrine Sensitivity Index Validation Dataset
Validation dataset of 298 ER-positive patients treated with tamoxifen for 5 years. All patients in this dataset have ER+ breast cancer and were uniformly treated with tamoxifen for 5 years. The objective of the study was to correlate levels of genomic markers to outcomes (relapse free survival) in ...
ORGANISM(S): Homo sapiens 
2010-08-13 | E-GEOD-17705 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (methylation data)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-20712 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (methylation data 2)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-22249 | biostudies-arrayexpress
TranscriptomicsEpigenetic portraits of human breast cancers (HCT116 cell line data)
Breast cancer is a molecularly, biologically and clinically heterogeneous group of disorders. Understanding this diversity is essential to improving diagnosis and optimising treatment. Both genetic and acquired epigenetic abnormalities participate in cancer, but information is scant on the involveme...
ORGANISM(S): Homo sapiens 
2011-10-18 | E-GEOD-20868 | biostudies-arrayexpress
TranscriptomicsGlobal MicroRNA Expression Profiling Identifies MiR-210 Associated with Tumor Proliferation, Invasion and Poor Clinical Outcome in Breast Cancer
In order to improve our understanding of breast cancer (BC) biology and its prognostication, global miRNA expression profiling was performed using microarray technology on systemically untreated BC patients with long-term follow up. In this study, global miRNA expression profiling using microarray t...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-28321 | biostudies-arrayexpress
TranscriptomicsGGI: a potential predictor of relapse for endocrine-treated breast cancer patients in the BIG 1-98 trial
Background: We have previously shown that the Gene expression Grade Index (GGI) was able to identify two subtypes of estrogen receptor (ER)-positive tumors that were associated with statistically distinct clinical outcomes in both untreated and tamoxifen-treated patients. Here, we aim to investigate...
ORGANISM(S): Homo sapiens 
2009-07-09 | E-GEOD-16391 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human breast cancer during pregnancy
Using a dataset of 54 pregnant and 113 age/stage-matched non-pregnant breast cancer patients with complete clinical and survival data; we evaluated the pattern of hot spot somatic mutations and performed transcriptomic profiling using Sequenom® and Affymetrix®, respectively. Breast cancer molecular ...
ORGANISM(S): Homo sapiens 
2014-09-09 | E-GEOD-53031 | biostudies-arrayexpress
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