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UnknownFOLFOX/FOLFIRI pharmacogenetics: the call for a personalized approach in colorectal cancer therapy.
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S-EPMC4130839 | biostudies-literature
TranscriptomicsThe expression profile of SLC transporter genes in resectable pancreatic cancer
Objectives: The aim of this study was to investigate the prognostic significance of thirteen anticancer drug-relevant solute carrier transporters (SLCs) in pancreatic cancer in the context of clinical-pathological characteristics and the KRAS mutation status of tumors. Methods: Tumors and non-neopla...
ORGANISM(S): Homo sapiens 
2013-06-30 | E-GEOD-47368 | biostudies-arrayexpress
TranscriptomicsThe expression profile of 5-fluorouracil pathway genes in colorectal carcinoma
This study addressed involvement of fourteen 5-fluorouracil pathway genes in the prognosis of colorectal carcinoma patients. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing 5-fluorouracil with therapy response and survival of colorectal carcinom...
ORGANISM(S): Homo sapiens 
2015-08-31 | E-GEOD-67111 | biostudies-arrayexpress
TranscriptomicsThe expression profile of ABC transporter genes in post-treatment breast carcinomas
ATP-binding cassette (ABC) transporters contribute to development of resistance to anti-cancer drugs via ATP-dependent drug efflux. A major goal of our study was to investigate associations between expression of ABC transporters and outcome of breast carcinoma patients. ABCA5/6/8/9/10, ABCB1/5/11, A...
ORGANISM(S): Homo sapiens 
2013-03-01 | E-GEOD-43807 | biostudies-arrayexpress
TranscriptomicsThe expression profile of cytochromes P450 (CYPs) and aldo-keto reductases (AKRs) in post-treatment breast carcinomas
Metabolism of anticancer drugs markedly affects their antitumor effects. The major goal of our study was to investigate associations of gene expression of enzymes metabolizing taxanes and/or anthracyclines with therapy response and survival of breast carcinoma patients AKR1A1 was significantly overe...
ORGANISM(S): Homo sapiens 
2014-08-31 | E-GEOD-56259 | biostudies-arrayexpress
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