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TranscriptomicsRNA-seq of ATDC5 cell-line with scrambled or Sox9 knockdown at 2 hours and 7 days in chondrocgenic differentiation.
Introduction: In addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early and a late (extracellular matrix associated) ph...
ORGANISM(S): Mus musculus 
2021-06-01 | E-MTAB-10333 | biostudies-arrayexpress
TranscriptomicsSOX9 regulated matrix proteins are increased in patients serum and correlate with severity of liver fibrosis
Extracellular matrix (ECM) deposition and resultant scar play a major role in the pathogenesis and progression of liver fibrosis. Identifying core regulators of ECM deposition may lead to urgently needed diagnostic and therapetic strategies for the disease. The transcription factor Sex determining r...
ORGANISM(S): Rattus norvegicus 
2019-07-01 | E-MTAB-7298 | biostudies-arrayexpress
ProteomicsSox9 determines translational capacity during early chondrogenic differentiation of ATDC5 cells by regulating expression of ribosome biogenesis factors and ribosomal proteins
Introduction: In addition to the well-known cartilage extracellular matrix-related expression of Sox9, we demonstrated that chondrogenic differentiation of progenitor cells is driven by a sharply defined bi-phasic expression of Sox9: an immediate early and a late (extracellular matrix associated) ph...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-18 | PXD024715 | Pride
Atdc5 Label-free proteomics Sox9 knockdown 
GenomicsExpression data from SOX9 knockdown in HCC cells
Expression data from SOX9 knockdown in HCC cells
PRJNA600736 | ENA
TranscriptomicsThe protein kinase MLTK Is a key regulator for chondrogenesis.
Sox9 acts together with Sox5 or Sox6 as a master regulator for chondrocyte differentiation; however, how these transcription factors functionally interact and collaborate to regulate chondrogenesis remains unclear. Here we show that the protein kinase MLTK plays an essential role in the onset of cho...
ORGANISM(S): Xenopus laevis 
2012-09-04 | E-GEOD-33767 | biostudies-arrayexpress
UnknownSOX9 Knockdown-Mediated FOXO3 Downregulation Confers Neuroprotection Against Ischemic Brain Injury.
Not available
S-EPMC8006459 | biostudies-literature
TranscriptomicsExpression data from SOX9 knockdown in HCC cells
Sorafenib is a multi-kinase blocker and one of the few suggested drug treatments for aggressive hepatocellular carcinoma (HCC) patients. However, drug resistance to sorafenib may often occur over time and cause further tumor aggression. Recently, cancer stem cells were found in HCC and were speculat...
ORGANISM(S): Homo sapiens 
2020-01-13 | GSE143477 | GEO
GenomicsSOX9 has distinct regulatory roles in alternative splicing and transcription
SOX9 has distinct regulatory roles in alternative splicing and transcription
PRJNA408241 | ENA
GenomicsAlteration in the transcriptome of lung basal epithelial cells isolated from IPF lungs upon genetic knockdown of SOX9
Alteration in the transcriptome of lung basal epithelial cells isolated from IPF lungs upon genetic knockdown of SOX9
PRJNA1199477 | ENA
UnknownDeciphering of SOX9 Functions in Pancreatic Cancer Cells.
Not available
S-EPMC11941869 | biostudies-literature
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