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ProteomicsA comparative study of synthetic winged peptides for absolute protein quantification
A proper internal standard choice is critical for accurate, precise, and reproducible mass spectrometry-based proteomics assays. Synthetic isotopically labeled (SIL) proteins are currently considered the gold standard. However, they are costly and challenging to obtain. An alternative approach uses ...
ORGANISM(S): Homo Sapiens 
2021-08-17 | PXD027985 | panorama
ProteomicsSimultaneous quantitative profiling of clinically relevant immune markers in neonatal stool swabs to reveal inflammation
An aberrant immune response developed early in life may trigger inflammatory bowel disease (IBD) and food allergies (e.g., celiac disease). Fecal levels of immune markers categorize an inflammatory response (e.g., food allergy, autoimmune) paralleled with the initial microbial colonization. The immu...
ORGANISM(S): Homo Sapiens 
2021-08-17 | PXD027988 | panorama
ProteomicsMultiplex assay for quantification of acute phase proteins and immunoglobulin A in dried blood spots
Inflammation is the first line defense mechanism against infection, tissue damage or cancer development. However, inappropriate inflammatory response may also trigger diseases. The quantification of inflammatory proteins is essential to distinguish between harmful and beneficial immune response. Cur...
ORGANISM(S): Homo Sapiens 
2018-12-05 | PXD011944 | panorama
ProteomicsProfiling Tryptophan Catabolites of Human Gut Microbiota and Acute-Phase Protein Levels in Neonatal Dried Blood Specimens
National screening programs use dried blood specimens to detect abnormal metabolism or aberrant protein function in infants shortly after birth, thus identifying disorders that are not clinically evident in the newborn period. Gut microbiota metabolites and immunological acute phase proteins are cap...
ORGANISM(S): Homo Sapiens 
2022-08-02 | PXD027606 | panorama
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