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TranscriptomicsDeep sequencing of MYC DNA-binding sites in Burkitt's lymphoma
Background: MYC is a transcription factor encoded by the c-MYC gene (thereafter termed MYC). MYC is key transcription factor involved in many central cellular processes including ribosomal biogenesis. MYC is overexpressed in the majority of human tumours including aggressive B-cell lymphoma especial...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30726 | biostudies-arrayexpress
TranscriptomicsMolecular classification of mature aggressive B cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens [Affymetrix]
The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared to mBL treated with chemotherapy regimens...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-48097 | biostudies-arrayexpress
TranscriptomicsMolecular classification of mature aggressive B cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens [FFPE]
The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared to mBL treated with chemotherapy regimens...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-48182 | biostudies-arrayexpress
TranscriptomicsMolecular classification of mature aggressive B cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens [Frozen tissue]
The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared to mBL treated with chemotherapy regimens...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-48183 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Sunitinib-treated but not untreated short-term serum-free cultures predict treatment response of human high-grade gliomas in vitro
High-grade gliomas are amongst the most deadly human tumors. Treatment results are overall disappointing. Nevertheless, in several trials around 20% of patients respond to therapy. Diagnostic strategies to identify those patients that will ultimately profit from a specific targeted therapy are urgen...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-51305 | biostudies-arrayexpress
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
TranscriptomicsGene expression changes in subclones of a Burkitt lymphoma cell line with different patterns of EBV latent infection
In this study we have investigated the gene expression profiles of three different types of subclone all generated by single cell cloning of the same parental EBV positive Burkitt lymphoma cell line Awia-BL. These included EBV negative clones which have lost the virus episome, EBV positive clones w...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-42867 | biostudies-arrayexpress
TranscriptomicsTranslocations Activating IRF4 Identify a Subtype of Germinal-Center-Derived B-cell Lymphoma Affecting Predominantly Children and Young Adults
Background: Germinal center B-cell (GCB) lymphomas are common in children and adults. The prognosis strongly depends on age. Subgroups of GCB-lymphomas are characterized by chromosomal translocations affecting immunoglobulin (IG) loci leading to oncogene deregulation. Methods: Novel IG translocation...
ORGANISM(S): Homo sapiens 
2011-06-24 | E-GEOD-22470 | biostudies-arrayexpress
UnknownDetection of genomic aberrations in molecularly defined Burkitt's lymphoma by array-based, high resolution, single nucleotide polymorphism analysis.
Not available
S-EPMC2995562 | biostudies-literature
UnknownGene expression-based outcome prediction in advanced stage classical Hodgkin lymphoma treated with BEACOPP.
Not available
S-EPMC8632672 | biostudies-literature
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