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TranscriptomicsDetecting novel genes with sparse arrays
Species-specific genes play an important role in defining the phenotype of an organism. However, current gene prediction methods can only efficiently find genes that share features such as sequence similarity or general sequence characteristics with previously known genes. Novel sequencing methods a...
ORGANISM(S): Hypocrea jecorina 
2010-08-12 | E-GEOD-12960 | biostudies-arrayexpress
TranscriptomicsGene expression data from hCdc73 knock-down HEK293 cells under confluent and sparse condition.
The parafibromin/hCdc73 is a component of the PAFc, which controls RNA polymerase II-mediated general transcription. In parathyroid carcinoma and familial autosomal dominant hyperparathyroidism-jaw tumor (HPT-JT), hCdc73 mutations are heavily implicated, yet the underlying mechanism of its carcinoge...
ORGANISM(S): Homo sapiens 
2014-09-23 | E-GEOD-61601 | biostudies-arrayexpress
GenomicsEpiclomal: probabilistic clustering of sparse single-cell DNA methylation data
We present Epiclomal, a probabilistic clustering method arising from a hierarchical mixture model to simultaneously cluster sparse single-cell DNA methylation data and infer their corresponding hidden methylation profiles. Using synthetic and published single-cell CpG datasets we show that Epiclomal...
EGAS00001003504 | EGA
GenomicsCodependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data
Codependency and mutual exclusivity for gene community detection from sparse single-cell transcriptome data
PRJNA604221 | ENA
TranscriptomicsTranscription profiling of human HUVECs before and after Angiopoietin stimulation
Angiopoietin-Tie2 sytem has been inplicated in both vascular quiescence and angiogenesis. It is unclear how these two opposing signals are regulated from the same receptor-mediated intracellular signal transduction. We have noticed that Tie2 localization upon Angiopoietin stimulation depends upon th...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-9677 | biostudies-arrayexpress
GenomicsSparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
Sparse CBX2 nucleates many Polycomb proteins to promote facultative heterochromatinization of Polycomb target genes
PRJNA1075128 | ENA
UnknownSparse Regression by Projection and Sparse Discriminant Analysis.
Not available
S-EPMC4560121 | biostudies-literature
TranscriptomicsNovel biomarkers for distributed stem cells: asymmetric self-renewal associated (ASRA) genes identification by combined cDNA micro-array orthogonal intersection and sparse feature analysis
Biomarkers unique for distributed stem cells (DSCs) have proven elusive. Previous searches for proteins expressed specifically in DSCs were hampered by difficulty obtaining pure DSCs and challenges to successfully mining complex molecular expression data. To identify novel candidates for DSC bioma...
ORGANISM(S): Mus musculus 
2014-06-30 | E-GEOD-40183 | biostudies-arrayexpress
GenomicsSingle-cell nascent transcription reveals sparse genome usage and plasticity [single_cell]
Single-cell nascent transcription reveals sparse genome usage and plasticity [single_cell]
PRJNA1168887 | ENA
GenomicsSingle-cell nascent transcription reveals sparse genome usage and plasticity [EU_seq]
Single-cell nascent transcription reveals sparse genome usage and plasticity [EU_seq]
PRJNA1168886 | ENA
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