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ProteomicsInsights into the role of de novo fatty acid synthesis in IL-17-producing γδ T cells upon psoriatic inflammation
γδ T cells produce the primary innate source of IL-17 (γδT17) and are known to play a critical role in autoimmune and inflammatory diseases such as psoriasis. We here reported that psoriatic condition (IL-1b and IL-23) reshaped metabolic signatures and effector function of γδT17 cells compared to ho...
ORGANISM(S): Mus Musculus (mouse) 
2025-02-20 | PXD050505 | JPOST Repository
TranscriptomicsSequential induction of effector function, tissue migration and cell death during polyclonal activation of regulatory T-cells
The ability of Treg-cells to produce interleukin-10 (IL-10) is important for the limitation of inflammation at environmental interfaces like colon or lung. Under steady state conditions, however, only few Treg-cells produce IL-10 ex vivo. To investigate the origin and fate of IL-10 producing Tregc...
ORGANISM(S): Mus musculus 
2013-08-10 | E-GEOD-41492 | biostudies-arrayexpress
TranscriptomicsDusp9 expression and function in dendritic cells
Plasmacytoid dendritic cells (pDC) efficiently produce large amounts of type I interferon in response to TLR7 and TLR9 ligands, whereas conventional DCs (cDC) predominantly secrete high levels of the cytokines IL-10 and IL-12. The molecular basis underlying this distinct phenotype is not well unders...
ORGANISM(S): Mus musculus 
2015-06-26 | E-GEOD-54120 | biostudies-arrayexpress
TranscriptomicsS mansoni infection B cell comparison
The helminth Schistosoma Mansoni is known to generate a regulatory B cell population that can suppress in multiple murine experimental models. Microarray comparison allows for a greater understanding as to how these cells are generated and their implications in immune regulation.
ORGANISM(S): Mus musculus 
2014-03-28 | E-MTAB-2100 | biostudies-arrayexpress
TranscriptomicsGene expression of murine iDCs isolated from tolerized MOG35-55-infused/MOG35-55-immunized or MOG35-55-immunized mice
Recent data from our group, demonstrate that infusion of myelin oligodendrocyte glycoprotein (MOG35-55) peptide, leads to induction of MOG35-55-specific Tregs and subsequent suppression of Experimental Autoimmune Encephalomyelitis (EAE), the mouse model of multiple sclerosis. Amelioration of EAE was...
ORGANISM(S): Mus musculus 
2015-04-20 | E-GEOD-47210 | biostudies-arrayexpress
TranscriptomicsRNA-seq of blood samples from patients diagnosed with visceral leishmaniasis and asymptomatic individuals (Brazil)
To ascertain which genes are involved in the outcome of Leishmania infantum infection and immunopathology of human visceral leishmaniasis (VL), we investigated the transcriptional profile of whole blood samples from patients diagnosed with active VL compared to asymptomatic individuals (positive ser...
ORGANISM(S): Homo sapiens 
2020-08-06 | E-MTAB-8818 | biostudies-arrayexpress
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