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MetabolomicsAlcohol-Induced Bone Loss: Driven by Dysregulated Spatial Distribution of Gut Microbiota and PGD2-IL17 Pathway-Mediated Osteoclast Activation

Purpose: Alcohol-induced damage to bone microstructure leads to alcoholic osteopenia (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic altera...

2025-03-28 | MTBLS11887 | MetaboLights
UnknownProgramming Spatial Cell Sorting by Engineering Cadherin Intracellular Activity.
Not available
S-EPMC11197096 | biostudies-literature
GenomicsHigh-speed fluorescence image-enabled cell sorting
High-speed fluorescence image-enabled cell sorting
PRJNA705647 | ENA
TranscriptomicsSpatial transcriptomics from clinically non inflammed human lymph nodes
Because of their central role in inflammatory processes pathological alterations in lymph nodes can affect innate and adaptive immunity. However, interpretation of lymph node pathology in humans is hampered by the lack of a reference under homeostatic conditions and a limited understanding of the mo...
ORGANISM(S): Homo sapiens 
2025-03-31 | E-MTAB-13861 | biostudies-arrayexpress
Genomics
Spatial Sorting of mouse hepatocytes
PRJNA556572 | ENA
ProteomicsA vascular phosphoproteome atlas unveils a functional Tie‑Wnt signalling axis in the liver
Single cell transcriptomic analyses (scRNAseq) of hepatocytes and liver endothelial cells (L-EC) have revolutionized the understanding of the spatial architecture of liver structure and function. The spatial alignment of L-EC and hepatocytes is pivotal for liver function in health and disease given ...
ORGANISM(S): Mus musculus (Mouse) 
2021-05-20 | PXD020760 | Pride
Multi-omics Vasculature Liver Endothelial Phospho proteome Spatial sorting Zonation 
ProteomicsSpatial Multi-Omics Reveals Region-Specific Molecular Signatures in a 6-OHDA Model of Parkinson’s Disease
Parkinson’s disease (PD) is characterized by complex molecular and circuit-level alterations that extend beyond dopaminergic neurodegeneration, yet the spatial integration of metabolic and proteomic changes remains insufficiently explored. Here, we combined time-of-flight secondary ion mass spectrom...
ORGANISM(S): Mus musculus (Mouse) 
2026-09-28 | PXD071834 | Pride
UnknownXenomake: a pipeline for processing and sorting xenograft reads from spatial transcriptomic experiments.
Not available
S-EPMC10508769 | biostudies-literature
UnknownXenomake: a pipeline for processing and sorting xenograft reads from spatial transcriptomic experiments.
Not available
S-EPMC11583937 | biostudies-literature
ProteomicsDevelopment of a sensitive, scalable method for spatial, cell-type-resolved proteomics of the human brain
While nearly comprehensive proteome coverage can be achieved from bulk tissue or cultured cells, the data usually lacks spatial resolution. As a result, tissue based proteomics averages protein abundance across multiple cell types and/or localisations. With proteomics platforms lacking sensitivity a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-04 | PXD012101 | Pride
Tissue proteomics Lc-ms/ms Brain Laser capture microdissection Spatially resolved proteomics 
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