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MetabolomicsUntargeted metabolomics reveals species-specific metabolite production and shared nutrient consumption by Pseudomonas aeruginosa and Staphylococcus aureus

While bacterial metabolism is known to impact antibiotic efficacy and virulence, the metabolic capacities of individual microbes in cystic fibrosis lung infections are difficult to disentangle from sputum samples. Here, we show that untargeted metabolomic profiling of supernatants of multiple str...

2021-05-26 | MTBLS2105 | MetaboLights
MetabolomicsPhototrophic biofilm assembly in microbial-mat-derived unicyanobacterial consortia: model systems for the study of autotroph-heterotroph interactions
Microbial autotroph-heterotroph interactions influence biogeochemical cycles on a global scale, but the diversity and complexity of natural systems and their intractability to in situ manipulation make it challenging to elucidate the principles governing these interactions. The study of assembling p...
2014-06-24 | MTBLS75 | MetaboLights
TranscriptomicsDecoding breast cancer tissue-stroma interactions using species-specific sequencing
Decoding genome-wide effects of experimental tissue-tissue or cell-cell interactions is important, for example, to better understand tumor-stroma interactions after transplantation (xenografting). Transcriptome analysis of intermixed human and mouse cells has frequently relied on the need to separat...
ORGANISM(S): Homo sapiens 
2015-08-12 | E-GEOD-66744 | biostudies-arrayexpress
GenomicsUnderstanding species-specific and conserved RNA-protein interactions in vivo and in vitro
Understanding species-specific and conserved RNA-protein interactions in vivo and in vitro
PRJNA1092528 | ENA
ModelsProctor2011_ProteinHomeostasis_NormalCondition
This model is from the article: Modelling the Role of the Hsp70/Hsp90 System in the Maintenance of Protein Homeostasis Proctor CJ, Lorimer IAJ PLoS ONE2011; 6(7): e22038. doi:10.1371/journal.pone.0022038, Abstract: Neurodegeneration is a...
2024-09-02 | BIOMD0000000344 | BioModels
MetabolomicsMulti-omic analysis of vaginal bacteria:host immune and metabolic interactions in early adverse pregnancy outcomes

Objective

To characterise the vaginal microbiota, mucosal metabolome and host immune response in early pregnancy and investigate its relationship with adverse pregnancy outcomes, including ectopic pregnancy, within the context of pregnancies of unknown location (PUL).

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2025-03-28 | MTBLS10098 | MetaboLights
TranscriptomicsUnderstanding species-specific and conserved RNA-protein interactions in vivo and in vitro
While evolution is often considered from a DNA- and protein-centric view, RNA-based regulation can also impact gene expression and protein sequences. Here we examined interspecies differences in RNA-protein interactions using the conserved neuronal RNA-binding protein, Unkempt (UNK) as model. We fin...
ORGANISM(S): synthetic construct Mus musculus Homo sapiens Pan troglodytes 
2024-07-29 | GSE262560 | GEO
TranscriptomicsGenetic and molecular basis of drug resistance and species-specific drug action in Schistosome parasites
Oxamniquine resistance evolved in the human blood fluke (Schistosoma mansoni) in Brazil in the 1970s. We crossed parental parasites differing ~500-fold in drug response, determined drug sensitivity and marker segregation in clonally-derived F2s, and identified a single QTL (LOD=31) on chromosome 6. ...
ORGANISM(S): Schistosoma mansoni 
2013-12-05 | E-GEOD-51847 | biostudies-arrayexpress
ProteomicsRecurrent innovation of protein-protein interactions in the Drosophila piRNA pathway
Despite being essential for fertility, genome defence pathway genes often evolve rapidly. However, little is known about the molecular basis of this adaptation. Here, we characterize the evolution of a protein interaction network within the PIWI-interacting small RNA (piRNA) genome defence pathway i...
ORGANISM(S): Drosophila persimilis Drosophila simulans Drosophila virilis Drosophila melanogaster (Fruit fly) Drosophila erecta 
2024-10-05 | PXD053049 | Pride
Pirna pathway Inter and intra lethalities Drosophila Species-specific protein interactions Evolution 
UnknownUnderstanding species-specific and conserved RNA-protein interactions in vivo and in vitro.
Not available
S-EPMC11436793 | biostudies-literature
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