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GenomicsDNA specificity determinants associate with distinct transcription factor functions
To elucidate how genomic sequences build transcriptional control networks we need to understand the connection between DNA sequence and transcription factor binding and function. Binding predictions based solely on consensus predictions are limited because a single factor can use degenerate sequenc...
ORGANISM(S): Homo sapiens 
2009-12-18 | E-GEOD-17954 | biostudies-arrayexpress
TranscriptomicsRunx1 deficiency decreases ribosome biogenesis and confers stress resistance to hematopoietic stem and progenitor cells
The transcription factor RUNX1 is frequently mutated in myelodysplastic syndrome and leukemia. RUNX1 mutations can be early events, creating pre-leukemic stem cells that expand in the bone marrow. Here we show that, counter-intuitively, Runx1 deficient hematopoietic stem and progenitor cells (HSPCs)...
ORGANISM(S): Mus musculus 
2015-07-27 | E-GEOD-67609 | biostudies-arrayexpress
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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