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UnknownInflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis.
Not available
S-EPMC8020656 | biostudies-literature
TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (RNA-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52623 | biostudies-arrayexpress
MetabolomicsPlasma Lipidomics Identifies Anticedent Memory Impairment in Older Adults
Alzheimer's disease causes a progressive dementia that currently affects over 35 million individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no cures or disease-modifying therapies, and this may be due to our inability to detect the disease before it has progresse...
2014-03-09 | MTBLS72 | MetaboLights
UnknownThe effect of LRRK2 loss-of-function variants in humans.
Not available
S-EPMC7303015 | biostudies-literature
GenomicsEGAS00001000212-sc-20120201 - samples
MuTHER adipose tissue small RNA expression
EGAD00001000105 | EGA
GenomicsMuTHER adipose tissue small RNA expression
We investigate the naturally occurring variation of small RNA expression in conjunction with genetic and gene expression variation. We shall assess the variation in subabdominal fat tissue small RNA levels in 168 unrelated MuTHER individuals. Using gene expression data from the same samples, we can ...
EGAS00001000212 | EGA
UnknownGWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.
Not available
S-EPMC6386176 | biostudies-literature
GenomicsBMI EWAS summary stats
Summary statistics for a multi-cohort epigenome-wide association study. This includes summary statistics (effect-size, standard error, p-value) for 470,000 methylation markers.
EGAD00010001029 | EGA
GenomicsDNA methylation and the adverse metabolic outcomes of adiposity
Overweight and obesity affect ~1.5 billion people worldwide, and are major risk factors for type-2 diabetes (T2D), cardiovascular disease and related metabolic and inflammatory disturbances.1,2 Although the mechanisms linking adiposity to its clinical sequelae are poorly understood, recent studies s...
EGAS00001001922 | EGA
UnknownBaseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial.
Not available
S-EPMC10336619 | biostudies-literature
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