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TranscriptomicsSensory experience restricts cortical plasticity by inducing IGF-1 in VIP neurons
RNA-seq libraries purified from the visual cortices of neurons expressing Emx-, GAD2-, PV-, SST-, or VIP-Cre using the Ribotag allele. Seq libraries are provided from mice raised in standard housing, or housed in the dark for two weeks (dark-housed), or dark-housed and then exposed to light for 1, ...
ORGANISM(S): Mus musculus 
2016-03-17 | E-GEOD-77243 | biostudies-arrayexpress
TranscriptomicsIdentification of activity-induced Npas4-regulated genes in cortical inhibitory and excitatory neurons (array)
To identify the activity-induced gene expression programs in inhibitory and excitatory neurons, we analyzed RNA extracted from cultured E14 mouse MGE- and CTX-derived neurons (DIV 10) after these cultures were membrane-depolarized for 0, 1 and 6 hrs with 55mM extracellular KCl. To identify the gene ...
ORGANISM(S): Mus musculus 
2015-06-04 | E-GEOD-55588 | biostudies-arrayexpress
TranscriptomicsAn increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene [array]
We studied the response to increased DNA-supercoiling in Streptococcus pneumoniae by using seconeolitsine (SCN), a DNA topoisomerase I inhibitor. A homeostatic transcriptional response allowing recovering of supercoiling density was observed in cells treated with subinhibitory SCN concentrations. Su...
ORGANISM(S): Streptococcus pneumoniae R6 
2016-07-07 | E-GEOD-77587 | biostudies-arrayexpress
TranscriptomicsAn increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene [RNA-Seq]
We studied the response to increased DNA-supercoiling in Streptococcus pneumoniae by using seconeolitsine (SCN), a DNA topoisomerase I inhibitor. A homeostatic transcriptional response allowing recovering of supercoiling density was observed in cells treated with subinhibitory SCN concentrations. Su...
ORGANISM(S): Streptococcus pneumoniae R6 
2016-07-07 | E-GEOD-77748 | biostudies-arrayexpress
TranscriptomicsIdentification of activity-induced genes in cortical inhibitory neurons (RNA-Seq)
To identify the activity-induced gene expression programs in inhibitory neurons, we analyzed RNA extracted from cultured E14 mouse MGE-derived neurons (DIV 10) after these cultures were membrane-depolarized for 0, 1 and 6 hrs with 55mM extracellular KCl. Mouse E14 MGE-derived neurons were cultured f...
ORGANISM(S): Mus musculus 
2014-05-22 | E-GEOD-55590 | biostudies-arrayexpress
TranscriptomicsHippocampal expression data from FTY720- and vehicle-treated SCID mice following fear consolidation testing
FTY720/Fingolimod, an FDA-approved drug for treatment of multiple sclerosis, has beneficial effects in the CNS that are not yet well understood, independent of its effects on immune cell trafficking. Here we show that FTY720 enters the nucleus where it is phosphorylated by sphingosine kinase 2 (SphK...
ORGANISM(S): Mus musculus 
2014-05-12 | E-GEOD-57015 | biostudies-arrayexpress
TranscriptomicsNHGRI Menin ChIP-Chip
Multiple endocrine neoplasia type I (MEN1) is a familial cancer syndrome characterized primarily by tumors of multiple endocrine glands. The gene for MEN1 encodes a ubiquitously expressed tumor suppressor protein called menin. Menin was recently shown to interact with several components of a trithor...
ORGANISM(S): Homo sapiens 
2006-07-24 | E-GEOD-5357 | biostudies-arrayexpress
TranscriptomicsExpression profiling analysis of lung, heart and bone of AGA002 mutant mice
Col1a1 is located on mouse distal chromosome 11 (Celera 94607393-94622990bp; 15kb) and encodes type I procollagen that associates stoichiometrically with col1a2 in forming secreted type I mature collagen that self-assembles into a supramolecular fibrillar structure consisting of a protein family. Ty...
ORGANISM(S): Mus musculus 
2010-06-01 | E-GEOD-12847 | biostudies-arrayexpress
UnknownPost-Wildfire Indoor Pollution in WUI Areas following the 2025 Los Angeles Fires. Part I. Establishing Baseline Contaminant Levels Prior to Home Reoccupation.
Not available
S-EPMC12797226 | biostudies-literature
TranscriptomicsExpression profiling analysis of NOX4 mutant mouse model
NADPH oxidases are the only know enzyme family that has reactive oxygen species (ROS, e.g. superoxide and hydrogen peroxide) as their main metabolic product. They are therefore a prima candidate gene family to define a molecular source for ROS in physiology and pathophysiology. The type 4 NADPH oxid...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-20400 | biostudies-arrayexpress
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