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TranscriptomicsPGC-1 alpha isoforms and muscle hypertrophy
An alternative promoter of the PGC-1 alpha gene gives arrise to 3 new isofroms of the PGC-1 alpha gene refered to as PGC-1a2 (A2), PGC-1a3 (A3) and PGC-1a4 (A4). The proximal PGC-1 alpha promotor transcribes the canonical PGC-1 alpha which is refered to as PGC-1a1 (A1).G1/G2/G3 samples refer to the ...
ORGANISM(S): Mus musculus 
2012-12-04 | E-GEOD-42473 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mice lacking exons 3 to 4 of the Pgc1beta gene (PGC1beta E3,4-/E3,4- mice) against wild type controls to study the role of PGC1beta in metabolism
PGC1beta is a transcriptional coactivator that potently stimulates mitochondrial biogenesis and respiration of cells. Here, we have generated mice lacking exons 3 to 4 of the Pgc1beta gene (PGC1beta E3,4-/E3,4- mice). These mice express a mutant protein that has reduced coactivation activity on a su...
ORGANISM(S): Mus musculus 
2009-04-24 | E-GEOD-6210 | biostudies-arrayexpress
TranscriptomicsImmortalized clonal brown, beige and white adipose cell lines
Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. Recent data suggest that there are two distinct types of brown fat: classical brown fat derived from a myf-5 cellular lineage and UCP1-positive cells that emerge in white fat from a non...
ORGANISM(S): Mus musculus 
2012-07-23 | E-GEOD-39562 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human A540 non small cell carcinoma cell lines reveals synergy between PPARgamma ligands and platinum-based drugs in cancer
PPARγ is a member of the nuclear receptor family for which agonist ligands have anti-growth effects. However, clinical studies using PPARγ ligands as a monotherapy failed to show a beneficial effect. Here we have studied the effects of PPARγ activation with chemotherapeutic agents in current us...
ORGANISM(S): Homo sapiens 
2009-04-30 | E-GEOD-7035 | biostudies-arrayexpress
TranscriptomicsExpression data from the subclones of Lewis Lung Carcinoma (LLC) cells
Medium conditioned by LLC cells stimulates thermogenic gene expression when added onto primary adipocytes. We generated single cell colonies from parental LLC cells. Media conditioned by the subclones stimulated thermogenic gene expression in primary adipocytes at varying degrees. Subclones 2, 3, 6 ...
ORGANISM(S): Mus musculus 
2014-07-13 | E-GEOD-57797 | biostudies-arrayexpress
TranscriptomicsExpression data from multiple mouse adipose depots
Comparing gene expression profiles of murine subcutaneous vs. visceral adipose tissue. Gene expression was analyzed in two subcutaneous depots (inguinal and axillary) and two visceral depots (epididymal and mesenteric) from male C57Bl/6 mice. 4 samples were analyzed as two groups: inguinal and axill...
ORGANISM(S): Mus musculus 
2014-01-16 | E-GEOD-53307 | biostudies-arrayexpress
TranscriptomicsGene expression profile after TRPV4 knockdown in 3T3-F442A adipocytes
Comparing gene expression profile in 3T3-F442A adipocytes with shRNA against TRPV4 or GFP. TRPV4 is an ion channel expressed in adipocytes. Results provided information that how loss-of-function of TRPV4 affects gene expression in adipocytes. 4 samples were analyzed as two groups: shGFP (control) an...
ORGANISM(S): Mus musculus 
2012-10-12 | E-GEOD-40280 | biostudies-arrayexpress
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