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GenomicsLoss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors
Loss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors
PRJNA811500 | ENA
TranscriptomicsLoss of Spindly sensitizes EML4-ALK v3 lung cancer cells to HSP90 inhibitors
Heat Shock Protein 90 inhibitors (HSP90i) have shown encouraging activity in EML4-ALK+ non-small cell lung cancer (NSCLC) patients but clinical responses have been heterogeneous. It has been suggested that distinct EML4-ALK variants may have a differential impact on the response to HSP90 inhibition....
ORGANISM(S): Homo sapiens 
2025-02-01 | GSE197655 | GEO
UnknownSpindly is required for rapid migration of human cells.
Not available
S-EPMC5992534 | biostudies-literature
UnknownKinetochore protein Spindly controls microtubule polarity in Drosophila axons.
Not available
S-EPMC7275735 | biostudies-literature
UnknownRequirement of the Dynein-Adaptor Spindly for Mitotic and Post-Mitotic Functions in Drosophila.
Not available
S-EPMC6027351 | biostudies-literature
UnknownSpindly/CCDC99 is required for efficient chromosome congression and mitotic checkpoint regulation.
Not available
S-EPMC2883941 | biostudies-literature
UnknownConformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin.
Not available
S-EPMC9481740 | biostudies-literature
UnknownUSP45 and Spindly are part of the same complex implicated in cell migration.
Not available
S-EPMC6158257 | biostudies-literature
UnknownMolecular mechanism of dynein recruitment to kinetochores by the Rod-Zw10-Zwilch complex and Spindly.
Not available
S-EPMC5379953 | biostudies-literature
UnknownPreventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.
Not available
S-EPMC4436830 | biostudies-literature
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