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MetabolomicsSponge exudates influence coral reef picoplankton dynamics
Coral reef sponges efficiently take up particulate and dissolved organic matter (DOM) from the water column and release compounds such as nucleosides, amino acids, and other dissolved metabolites to the surrounding reef via their exhalent seawater, but the influence of this process on reef picoplank...
2026-01-12 | MTBLS5747 | MetaboLights
MetabolomicsMolecular profiling of sponge movement reveals an ancient contractile-inflammatory response

A hallmark of animals is the coordination of whole-body movement. Neurons and muscles are central to this; yet, coordinated movements also exist in sponges that lack these cell types. Sponges are sessile animals with a complex canal system for filter-feeding. They undergo whole-body movements res...

2026-08-11 | MTBLS8137 | MetaboLights
MetabolomicsOceanographic setting influences the prokaryotic community and metabolome in deep-sea sponges
Marine sponges (phylum Porifera) are leading organisms for the discovery of bioactive compounds from nature. Their often rich and species-specific microbiota is hypothesised to be producing many of these compounds. Yet, environmental influences on the sponge-associated microbiota and bioactive compo...
2023-05-12 | MTBLS1388 | MetaboLights
ProteomicsIncreased cellular detoxification, cytoskeletal activities and protein transport explain physiological stress in a lagoon sponge
Tropical lagoon-inhabiting organisms live in highly irradiated ecosystems and are particularly susceptible to thermal stress resulting from climate change. However, despite living close to their thermal maxima, stress response mechanisms found in these organisms are poorly understood. We used a nove...
ORGANISM(S): Amphimedon 
2021-11-15 | PXD027246 | Pride
Proteomics Physiology Lagoon Thermal stress Sponge Climate change 
TranscriptomicsTranscriptomic profiles of two sponge species upon exposure to microbial-associated molecular patterns (lipopolysaccharide and peptidoglycan) compared against control (sterile artificial seawater)
The interaction of animals with microbes relies on the specific recognition of microbial-derived molecules by receptors of the immune system. Sponges (phylum Porifera), as sister group of the Eumetazoa, provide insights into conserved mechanisms for animal-microbe crosstalk, but empirical data is li...
ORGANISM(S): Dysidea avara 
2018-11-26 | E-MTAB-6757 | biostudies-arrayexpress
TranscriptomicsEffects of miR-106a~363 blocking sponge on Sk-ES-1 Ewing Sarcoma Cell line Gene Expression Profile
The objective of this study was to determine the effects of miR-106a~363 blockade on the gene expression profile of Ewing Sarcoma cell lines (Sk-ES-1 cells) Microarray analysis was performed on 3 samples from Sk-ES-1 cells stably expressing the control CXCR4 miRNA sponge and 3 samples from Sk-ES-1 c...
ORGANISM(S): Homo sapiens 
2013-12-01 | E-GEOD-45205 | biostudies-arrayexpress
TranscriptomicsGene expression profile from single cell level of retinal cells from optic cup of injected Abca4KO mice with miR-181a/b sponge therapeutic
We observed a beneficial effect on Abca4KO mice phenotype upon miR-181a/b sponge treatment. Then, we decided to perform single cell analysis to better understand the pathway associated with amelioration observed. Abca4KO mice were injected with miR-181a/b sponge in one eye and with a control vector ...
ORGANISM(S): Mus musculus 
2026-02-20 | E-MTAB-15988 | biostudies-arrayexpress
MetabolomicsInfluenza A virus H1N1 infection alters sphingolipid metabolism in A549 cells
This study investigates metabolic alterations in A549 cells infected with influenza A virus H1N1 (WSN strain). Untargeted metabolomics analysis was performed using liquid chromatography coupled with mass spectrometry (LC-MS) in both positive and negative ionization modes. The study aims to character...
2026-07-29 | MTBLS15182 | MetaboLights
ProteomicsCombined cellular and proteomics approach suggest differential processing of a native and a foreign vibrio in the sponge Halichondria panicea
Phagocytosis is a conserved cellular mechanism for food uptake, defense and general animal-microbe interactions in metazoans. How the discrimination and subsequent processing of native and foreign microbes is facilitated remains largely unknown in marine invertebrates. Thereto, we combined a recentl...
ORGANISM(S): Halichondria panicea 
2025-05-27 | PXD063400 | Pride
Phagocytosis Proteomics Sponge cells Lfq Fluorescence-activated cell sorting (facs) Lcms Vibrio isolates Sponge-microbe symbiosis 
TranscriptomicsmiR-132 knockdown in rat PC12 cells
rat PC-12 cells were infected with a lentivirus expressing a sponge cassette to knockdown the expression of miR-132. Agilent whole rat genome arrays were probed to screen for changes in miR-132 knockdown cells versus control infected cells.
ORGANISM(S): Rattus norvegicus 
2011-07-15 | E-MTAB-458 | biostudies-arrayexpress
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