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TranscriptomicsmicroRNA profiling of Sprague Dawley organs
We performed deep sequencing of the miRNAs present in ~20 toxicologically relevant tissues in Sprague Dawley rats and used three independent analysis of the data to determine which miRNAs are tissue specific and tissue enriched. We performed deep sequencing of miRNAs in 21 organs from 5 male Sprague...
ORGANISM(S): Rattus norvegicus 
2016-09-01 | E-GEOD-78031 | biostudies-arrayexpress
TranscriptomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (RNE)
While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been assessed individually in separate studies, limited data on the inhalation toxicity of them is available when in mixtures. In this 90-day subchron...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5910 | biostudies-arrayexpress
TranscriptomicsToxicity of Toxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (Liver)
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5544 | biostudies-arrayexpress
TranscriptomicsToxicity of the main electronic cigarette components, propylene glycol, glycerin and nicotine in Sprague Dawley rats in a 90-day OECD inhalation study complemented with molecular endpoints (Lung)
The main constituents of electronic cigarette liquids are nicotine, propylene glycol (PG), and vegetable glycerin (VG), together with distilled water and flavors. To assess the toxicity of PG/VG mixtures with and without nicotine as basic components of liquids used in e-cigarettes, a 90-day rat inha...
ORGANISM(S): Rattus norvegicus 
2017-11-03 | E-MTAB-5545 | biostudies-arrayexpress
TranscriptomicsThirteen-week Nose-only Inhalation Exposures of Propylene Glycol Aerosols in Sprague Dawley Rats with a Lung Systems Toxicology Analysis.
Propylene glycol (PG) is a common carrier in e-vapor formulations and its properties have been extensively studied. In this 13-week subchronic nose-only inhalation study, Sprague Dawley rats were exposed to filtered air (sham control group), propylene glycol/water (PG/W; 90:10) or a propylene glycol...
ORGANISM(S): Rattus norvegicus 
2021-09-07 | E-MTAB-10006 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat kidney samples from Dahl SS/J and Sprague Dawley animals placed on high salt and basal salt diets
Serum and glucocorticoid-induced kinase 1 (SGK1) activates the epithselial sodium channel (eNaC) in tubules. We examined renal SGK1 abundance in salt-adaptation and in salt-sensitive hypertension. Sprague-Dawley and Dahl salt-sensitive rats were placed on either 8% or 0.3% NaCl diets for 10 days. Pl...
ORGANISM(S): Rattus norvegicus 
2007-10-11 | E-GEOD-599 | biostudies-arrayexpress
Transcriptomics5-Day Gavage Study of Propylene glycol phenyl ether (PPH; CASRN 770-35-4) in Male Harlan Sprague Dawley Rats
The goal of this study was to characterize the potential toxicity and genomic benchmark dose of propylene glycol phenyl etherl in liver and kidney of male Harlan Sprague Dawley rats using a 5 day dose-response toxicogenomics study design. The 5 day study is used to quickly identify the dose levels ...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-GEOD-75656 | biostudies-arrayexpress
GenomicsIn vitro transcriptomic responses to thioacetamide-S-oxide exposure in Sprague-Dawley rat primary hepatocytes, renal tube epithelial, and cardiomyocytes
In vitro transcriptomic responses to thioacetamide-S-oxide exposure in Sprague-Dawley rat primary hepatocytes, renal tube epithelial, and cardiomyocytes
PRJNA555599 | ENA
Transcriptomics5-Day Gavage Study of Crude 4-Methylcyclohexanemethanol in Male Harlan Sprague Dawley Rats
The goal of this study was to characterize the potential toxicity and genomic benchmark dose of crude 4-methylcyclohexylmethanol in liver and kidney of male Harlan Sprague Dawley rats using a 5 day dose-response toxicogenomics study design. The 5 day study is used to quickly identify the dose level...
ORGANISM(S): Rattus norvegicus 
2015-12-31 | E-GEOD-75655 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat proximal femoral growthplate after mid-shaft fracture
Mid-shaft fracture stimulates bone lengthening by increasing linear growth at the growthplate. This project studied changes in mRNA in the proximal growthplate after a mid-shaft fracture in a rat model. Experiment Overall Design: Study of rat proximal femoral growthplate after mid-shaft fracture in...
ORGANISM(S): Rattus norvegicus 
2008-06-12 | E-GEOD-3298 | biostudies-arrayexpress
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