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TranscriptomicsSpt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast [RNA-seq]
Spt6 is a highly conserved histone chaperone that interacts directly with both RNA polymerase II and histones to regulate gene expression. To gain a comprehensive understanding of the requirements for this critical factor, we have performed genome-wide analyses of transcription, chromatin structure...
ORGANISM(S): Schizosaccharomyces pombe 
2013-10-09 | E-GEOD-49573 | biostudies-arrayexpress
TranscriptomicsControl of chromatin structure by Spt6 has different consequences in coding and regulatory regions
Spt6 is a highly conserved factor that carries out important functions in transcription and chromatin structure. To gain new insights into Spt6, we measured nucleosome occupancy along Saccharomyces cerevisiae chromosome III in an spt6 mutant and found that the level of nucleosomes is greatly reduced...
ORGANISM(S): Saccharomyces cerevisiae 
2010-12-01 | E-GEOD-21787 | biostudies-arrayexpress
TranscriptomicsFACT and Spt6 Prevent Cryptic Transcription by Impeding H2A.Z Loading in Gene Bodies
H2A.Z is a highly conserved histone variant involved in several key nuclear processes. It is incorporated into promoters by SWR-C-related chromatin remodeling complexes, but whether it is also actively excluded from non-promoter regions is not clear. Here, we provide genomic and biochemical evidence...
ORGANISM(S): Saccharomyces cerevisiae 
2015-05-12 | E-GEOD-62880 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of yeast with a C-terminal deletion of the RNA polymerase II elongation factor Spt6 or overexpression of Spt6
Influence of a C-terminal deletion of the RNA polymerase II elongation factor Spt6 on the transcription of the yeast genome. In parallel the influence of a Spt6 overexpression on gene expression is analyzed.
ORGANISM(S): Saccharomyces cerevisiae 
2009-04-08 | E-MEXP-2123 | biostudies-arrayexpress
TranscriptomicsHDACs and Phosphorylated Pol II CTD recruit Spt6 for cotranscriptional histone reassembly
Spt6 is a multifunctional histone chaperone involved in the maintenance of chromatin structure during elongation by RNA polymerase II (Pol II). Spt6 has a tandem SH2 (tSH2) domain within its C-terminus that recognizes Pol II CTD peptides phosphorylated on Ser2, Ser5 or Try1 in vitro. Deleting the tS...
ORGANISM(S): Saccharomyces cerevisiae 
2014-09-25 | E-GEOD-61713 | biostudies-arrayexpress
TranscriptomicsSpt6 Levels are Modulated by PAAF1 and 26S Proteasome to Regulate the HIV-1 LTR and a Subset of Cellular Genes involved in Cancer.
Effect of PAAF1 and Spt6 knock-down on gene expression. Total RNAs were extracted from HeLa-LTR-Luc cells in which PAAF1 or Spt6 had been knock down by a specific siRNA or HeLa-LTR-Luc cells that had been transfected with a control siRNA (“si Neg”). Differentially expressed genes in PAAF1 knock-down...
ORGANISM(S): Homo sapiens 
2012-05-28 | E-GEOD-32033 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of fission yeast silencing mutants
Array-based transcriptome analysis of spt6 deletant and spt6-K20.
ORGANISM(S): Schizosaccharomyces pombe 
2013-11-14 | E-MTAB-1373 | biostudies-arrayexpress
GenomicsSpt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast [Mnase-seq]
Spt6 is a highly conserved histone chaperone that interacts directly with both RNA polymerase II and histones to regulate gene expression. To gain a comprehensive understanding of the requirements for this critical factor, we have performed genome-wide analyses of transcription, chromatin structure...
ORGANISM(S): Schizosaccharomyces pombe 
2013-10-09 | E-GEOD-49572 | biostudies-arrayexpress
GenomicsSpt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Schizosaccharomyces pombe 
2013-10-09 | E-GEOD-49575 | biostudies-arrayexpress
TranscriptomicsSpt6 is required for heterochromatic silencing in the fission yeast Schizosaccharomyces pombe
Spt6 is a conserved factor, critically required for several transcription and chromatin related processes. We now show that Spt6 and its binding partner, Iws1, are required for heterochromatic silencing in Schizosaccharomyces pombe. Our studies demonstrate that Spt6 is required for silencing of al...
ORGANISM(S): Schizosaccharomyces pombe 
2011-10-20 | E-MTAB-738 | biostudies-arrayexpress
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