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MetabolomicsTraditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma
Carica papaya leaf decoction, an Australian Aboriginal remedy, has been used widely for its healing capabilities against cancer, with numerous anecdotal reports. In this study we investigated its in vitro cytotoxicity on human squamous cell carcinoma cells followed by metabolomic profiling of Carica...
2017-05-04 | MTBLS274 | MetaboLights
MetabolomicsMechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

Mechanistic study of the effects of salivary components from OSCC patients on tumor growth using a mouse model of oral squamous cell carcinoma

2025-08-01 | MTBLS12805 | MetaboLights
MetabolomicsSOX2 Drives Esophageal Squamous Carcinoma by Reprogramming Lipid Metabolism and Histone Acetylation Landscape

SOX2 is not only a pioneer transcription factor with critical roles in stem cell function and cell reprogramming but also a potent oncogene for a multitude of squamous cancers. How SOX2 exerts a potent oncogenic activity in squamous lineage is largely unknown. Here we uncovered SOX2 a p...

2025-08-07 | MTBLS7120 | MetaboLights
MetabolomicsMass spectrometry-based lipidomics of oral squamous cell carcinoma tissue reveals aberrant cholesterol and glycerophospholipid metabolism
Not available
ORGANISM(S): Homo sapiens 
ST001267 | MetabolomicsWorkbench
TranscriptomicsGenomic landscape of carcinogen induced mouse skin squamous cell carcinoma: RNA-sequencing
RNA-sequencing of induced murine squamous cell carcinoma.
ORGANISM(S): Mus musculus 
2015-04-16 | E-MTAB-2889 | biostudies-arrayexpress
MetabolomicsELAPOR1 induces the classical/progenitor subtype and contributes to reduced disease aggressiveness through metabolic reprogramming in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is a heterogeneous disease with distinct molecular subtypes described as classical/progenitor and basal-like/squamous PDAC. We hypothesized that integrative transcriptome and metabolome approaches can identify candidate genes whose inactivation contributes to ...
2024-04-02 | MTBLS9418 | MetaboLights
TranscriptomicsFunctional evidence that Drosha over-expression in cervical squamous cell carcinoma affects cell phenotype and microRNA profiles
Although gain of chromosome-5p is one of the most frequent DNA copy number imbalances in cervical squamous cell carcinoma (SCC), the genes that drive its selection remain poorly understood. In a previous cross-sectional clinical study we showed that the microRNA processor Drosha (located on chromoso...
ORGANISM(S): Homo sapiens 
2011-05-26 | E-GEOD-26177 | biostudies-arrayexpress
MetabolomicsBiomarker Discovery in Oral Cancer (OSMF & OSCC) and its severity

Oral squamous cell carcinoma (OSCC) is frequently the outcome of oral submucous fibrosis (OSMF), a common possibly premalignant disease. In our study, a cohort of 50 patients with OSCC and OSMF, along with 50 healthy controls, was analyzed to identify significant metabolic differences between the...

2024-10-23 | MTBLS11009 | MetaboLights
TranscriptomicsMethylation profiles of esophageal squamous cell carcinoma patients and cancer-free individual in Taiwan.
Genome wide DNA methylation profiling of tumor and normal samples with esophageal squamous cell carcinoma patients. The Illumina GolodenGate methylation cancer panel I was used to obtain DNA methylation profiles across approximately 1,505 CpGs in esophageal squemous cell carcinoma samples. Samples i...
ORGANISM(S): Homo sapiens 
2014-09-11 | E-GEOD-51287 | biostudies-arrayexpress
TranscriptomicsAnalysis of the gene expression profile in normal human epidermal keratinocytes and cutaneous squamous cell carcinoma cell lines
The incidence of keratinocyte-derived skin cancer, cutaneous squamous cell carcinoma (cSCC) is increasing worldwide making it the second most common metastatic skin cancer. We used microarrays to characterize gene expression profile in normal human epidermal keratinocytes (NHEK) and cSCC cell lines....
ORGANISM(S): Homo sapiens 
2015-08-27 | E-GEOD-66359 | biostudies-arrayexpress
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