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ProteomicsLapatinib-Induced Enhancement Of Mitochondrial Respiration In HER2-Positive SK-BR-3 Cells: Mechanism Revealed By Analysis Of Proteomic But Not Transcriptomic Data
Dual inhibitors of HER2 and EGFR, such as lapatinib, have shown significant efficacy for the therapy of HER2-positive breast cancer. Previous experiments showed that in cell cultures, the efficacy of lapatinib was significantly reduced by exposure to human serum and human epidermal growth factor (EG...
ORGANISM(S): Homo sapiens (Human) 
2024-09-26 | PXD054180 | Pride
Proteomics Squamous cell carcinoma sk-br-3 Her-targeted cancer therapy Drug resistance Tricarboxylic acid cycle tca Human blood serum Cellular respiration Lapatinib 
TranscriptomicsMicroarray analyses of microRNA expressions in comparison with immortal healthy mammary epithelial cells, breast cancer cells, and long-term-cultured breast cancer stem cells
RNA extraction and microarray analysis total RNA from immortalized normal mammary epithelial cells (184A1, MCF-12A), breast cancer cells (MDA-MB-231, MCF-7, MDA-MB-468, SK-BR-3), BCSC (MDA-MB-231SC, MCF-7SC, XM322, XM607). MDA-MB-231SC and MCF-7SC originating from breast cancer cell lines; XM322 and...
ORGANISM(S): Homo sapiens 
2017-12-01 | E-MTAB-5584 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 25 breast cancer cell lines grown in 2D and 3D tissue culture conditions
A comparison of gene expression profiles for 25 breast cancer cell lines grown in 2D and 3D tissue culture conditions
ORGANISM(S): Homo sapiens 
2007-05-02 | E-TABM-244 | biostudies-arrayexpress
TranscriptomicsTime course microarray data following GR activation in MCF10A-Myc breast cells
This series contain time course microarray data from MCF10A-Myc cells treated with either ethanol or Dexamethasone for 30 min, 2 hr, 4 hr, and 24 hr. This series contains three biological replicates that were analyzed as independent replicate experiments (data were normalized within each replicate e...
ORGANISM(S): Homo sapiens 
2006-06-01 | E-GEOD-4917 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of heterotypic interactions between cancer cells and osteoblasts in vitro
Bone is the most common site of breast cancer metastasis, and this type of metastasis is a main cause of morbidity. Because breast cancer is a heterogeneous disease, the interactions between the cancer cells and the skeletal host cells, such as osteoblasts, might be diverse. Thus far, these tumor-os...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29036 | biostudies-arrayexpress
UnknownCancer stem-like cells with increased expression of NY-ESO-1 initiate breast cancer metastasis.
Not available
S-EPMC6757292 | biostudies-literature
TranscriptomicsThe inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-19 | E-GEOD-62907 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and MCF7 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (MCF7) and cells that represented skeletal compartments (Normal Human (NH) Osteoblasts) wer...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29032 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and HMEC mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented healthy epithelial cell compartments (HMEC - human mammary epithelial cell) and cells that represented skeletal compartments (Norm...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29030 | biostudies-arrayexpress
TranscriptomicsNormal human osteoblasts and MDA-MB-231 mono and coculture
As a model for investigating changes in gene expression in response to epithelial-osteoblast interactions in bone metastases of breast carcinomas, cells that represented malignant epithelial cell compartments (MDA-MB-231) and cells that represented skeletal compartments (Normal Human (NH) Osteoblast...
ORGANISM(S): Homo sapiens 
2012-01-06 | E-GEOD-29033 | biostudies-arrayexpress
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