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GenomicsChIP-Seq of human breast cancer cell lines MCF-7 in the absence of hormone and after Estradiol treatment with antibody against Estrogen Receptor cofactors SRC1, SRC2, SRC3, CBP and p300
The Estrogen Receptor cofactors SRC1 (NCOA1, KAT13A), SRC2 (NCOA2, GRIP1, TIF2, KAT13C) , SRC3 (NCOA3, AIB1, KAT13B, Rac3) , CBP and p300 are assessed for their genome-wide chromatin binding capacities in the breast cancer cell line MCF7. To determine the Estrogen Receptor dependency of interactions...
ORGANISM(S): Homo sapiens 
2011-10-25 | E-MTAB-785 | biostudies-arrayexpress
GenomicsSRC2 and SRC3 cooperatively promote pathogenic function of Th17 cells via regulation of epigenetic activation
SRC2 and SRC3 cooperatively promote pathogenic function of Th17 cells via regulation of epigenetic activation
PRJNA552079 | ENA
UnknownSRC3 Is a Cofactor for RORγt in Th17 Differentiation but Not Thymocyte Development.
Not available
S-EPMC6344289 | biostudies-literature
TranscriptomicsSRC2 and SRC3 cooperatively promote pathogenic function of Th17 cells via regulation of epigenetic activation
Steroid receptor coactivator 3 (SRC3) was reported to regulates pathogenic Th17 cell differentiation in vitro and in vivo.However, the role of SRC2, another member of SRC family, and its relationship with SRC3 in the regulation of Th17 cell differentiation remain unknown. We used RNA-seq to study th...
ORGANISM(S): Mus musculus 
2022-07-20 | GSE133641 | GEO
TranscriptomicsER_cofactor_specificity_arrays
The Estrogen Receptor cofactors SRC1 (NCOA1, KAT13A), SRC2 (NCOA2, GRIP1, TIF2, KAT13C) , SRC3 (NCOA3, AIB1, KAT13B, Rac3) , CBP and p300 are assessed for their genome-wide chromatin binding capacities in the breast cancer cell line MCF7. To determine the Estrogen Receptor dependency of interactions...
ORGANISM(S): Homo sapiens 
2011-10-25 | E-MTAB-788 | biostudies-arrayexpress
GenomicsIntegrative genomics of gene regulation by estrogen receptors and and coregulators [ChIP-seq]
The closely related transcription factors (TFs), estrogen receptors ER? and ER?, regulate divergent gene expression programs and proliferative outcomes in breast cancer. Utilizing MCF-7 breast cancer cells with ER?, ER?, or both receptors as a model system to define the basis of differing response s...
ORGANISM(S): Homo sapiens 
2013-07-05 | E-GEOD-42348 | biostudies-arrayexpress
TranscriptomicsIntegrative genomics of gene and metabolic regulation by estrogen receptors α and β and coregulators [expression]
The closely related transcription factors (TFs), estrogen receptors ERα and ERβ, regulate divergent gene expression programs and proliferative outcomes in breast cancer. Utilizing MCF-7 breast cancer cells with ERα, ERβ, or both receptors as a model system to define the basis of differing response s...
ORGANISM(S): Homo sapiens 
2013-07-05 | E-GEOD-42347 | biostudies-arrayexpress
TranscriptomicsNcoa3 in mouse embryonic stem cells
This SuperSeries is composed of the following subset Series: GSE37262: A Nuclear Receptor Coactivator is Essential for Esrrb Activity and the Induction and Maintenance of the ES Cell State GSE40192: Global gene expression analysis of Ncoa3 knockdown in mouse embryonic stem cells Refer to individual ...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-40193 | biostudies-arrayexpress
Genomics
RNA-seq of Renal Tubular Cells in the RTEC-Specific SRC3 Knockout Mouse Model of IRI-AKI
PRJNA1194210 | ENA
GenomicsThe BTB-zinc finger transcription factor Abrupt acts as an epithelial oncogene in Drosophila through maintaining a progenitor-like cell state
The capacity of tumor cells to maintain continual overgrowth potential has been linked to the commandeering of normal self-renewal pathways. Using an epithelial cancer model in Drosophila we carried out an overexpression screen for oncogenes capable of cooperating with the loss of the epithelial api...
ORGANISM(S): Drosophila melanogaster 
2013-08-15 | E-GEOD-42928 | biostudies-arrayexpress
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