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TranscriptomicsGene expression changes in MV4-11 cells upon SMARCA4 knock-down and PFI-3 treatment
Pharmacological inhibition of the SMARCA4 bromodomain inhibited human leukemic cell proliferation, phenocopying SMARCA4 knockdown in these cells. We performed microarray analysis of global gene expression changes in MV4-11 cells after 6 days of PFI-3 treatment and after SMARCA4 knock-down. With this...
ORGANISM(S): Homo sapiens 
2015-07-12 | E-GEOD-67920 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression changes in AML cells after SMARCA4, SMARCD2 or DPF2 knock-down
We explored the role of SMARCA4 and the two Brahma associated factors SMARCD2 and DPF2 in leukaemia. We observed the selective requirement for these factors for leukemic cell expansion, as well as extended survival of mice transplanted with leukaemic cells with reduced expression of these genes. Gen...
ORGANISM(S): Homo sapiens 
2015-07-12 | E-GEOD-67923 | biostudies-arrayexpress
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