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KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma [RIP-seq]
KAT2A-driven succinylation of SRSF11 enforces spliceosome-mediated RAD52 splicing to promote homologous recombination and radioresistance in hepatocellular carcinoma [RNA-seq]
Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized. In this study, we systematically demonstrated that the spli...
ORGANISM(S): Homo sapiens 
2025-12-04 | GSE304384 | GEO
Posttranslational modification succinylation plays a pivotal role in tumorigenesis across malignancies, yet its mechanistic contributions to hepatocellular carcinoma (HCC) pathogenesis and therapeutic resistance remain poorly characterized. In this study, we systematically demonstrated that the spli...
ORGANISM(S): Homo sapiens 
2025-12-04 | GSE304385 | GEO
Next Generation Sequencing Facilitates Quantitative Analysis of si-nc and si-SRSF11 LOVO Transcriptomes
Neuronal alternative splicing is a key gene regulatory mechanism in brain. Yet the spliceosome machinery is insufficient to fully specify splicing complexity. In considering the role of the epigenome in activity-dependent alternative splicing, we and others find the histone modification, H3K36me3, t...
ORGANISM(S): Mus musculus 
2021-07-31 | GSE180988 | GEO
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare the difference of mRNA between si-nc and si-SRSF11 in LOVO cell line Methods: LOVO mRNA profiles of si-nc and si-SRSF11 were generated by deep sequencing, ...
ORGANISM(S): Homo sapiens 
2022-12-01 | GSE199094 | GEO
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