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TranscriptomicsPre-BCR Signaling induce IgK Locus Accessibility by functional redistribution of Enhancer-mediated chromatin Interactions
During B cell development the precursor B cell receptor (pre-BCR) checkpoint is thought to increase immunoglobulin k light chain (Igk) locus accessibility to the V(D)J recombinase. Accordingly, pre-B cells lacking the pre-BCR signaling molecules Btk or Slp65 showed reduced germline Vk transcription....
ORGANISM(S): Mus musculus 
2014-03-21 | E-GEOD-53896 | biostudies-arrayexpress
TranscriptomicsHow C/EBPa creates an elite cell state for reprogramming to pluripotency [4C]
Mouse Bcell, upon ectopic expression of the transcription factor Cebpa for 18h, can be reprogrammed to iPS with extremely high efficiency. To understand the molecular control of this phenomena we performed multiple high throughtput functionnal genomic analysis. Circularized chromosome conformation c...
ORGANISM(S): Mus musculus 
2016-02-19 | E-GEOD-75481 | biostudies-arrayexpress
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