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UnknownIdentification of lectin receptors for conserved SARS-CoV-2 glycosylation sites.
New SARS-CoV-2 variants are continuously emerging with critical implications for therapies or vaccinations. The 22 N-glycan sites of Spike remain highly conserved among SARS-CoV-2 variants, opening an avenue for robust therapeutic intervention. Here we used a comprehensive library of mammalian carbo...
S-EPMC8420505 | biostudies-literature
UnknownA molecularly engineered, broad-spectrum anti-coronavirus lectin inhibits SARS-CoV-2 and MERS-CoV infection in vivo.
"Pan-coronavirus" antivirals targeting conserved viral components can be designed. Here, we show that the rationally engineered H84T-banana lectin (H84T-BanLec), which specifically recognizes high mannose found on viral proteins but seldom on healthy human cells, potently inhibits Middle East respir...
S-EPMC9519379 | biostudies-literature
UnknownFIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder
Whole exome sequencing of two patients with idiopathic complex neurodevelopmental disorder (NDD) identified biallelic variants of unknown significance within FIBCD1, encoding an endocytic acetyl-group binding transmembrane receptor with no known function in the central nervous system. We found that ...
S-SCDT-EMM-2022-15829 | biostudies-other
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