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TranscriptomicsKupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity.
Kupffer cells have been implicated in the pathogenesis of various liver diseases. However, their involvement in metabolic disorders of the liver, including fatty liver disease, remains unclear. The present study sought to determine the impact of Kupffer cells on hepatic triglyceride storage and to e...
ORGANISM(S): Mus musculus 
2011-10-17 | E-GEOD-33044 | biostudies-arrayexpress
Transcriptomicsgporez_affydata
To identify genes regulated by FXR in mouse liver, we compared gene expression profiles in livers of FXR+/+ (wt) and liver-specific FXR KO (lKO) mice
ORGANISM(S): Mus musculus 
2013-07-01 | E-MTAB-1722 | biostudies-arrayexpress
GenomicsGenome-wide profiling of LXR, RXR and PPARM-NM-1 in mouse liver reveals extensive sharing of binding sites
The liver X receptors (LXRs) are nuclear receptors that form permissive heterodimers with retinoid X receptor (RXR) and are important regulators of lipid metabolism in the liver. We have recently shown that RXR agonist-induced hypertriglyceridemia and hepatic steatosis in mice is dependent on LXR an...
ORGANISM(S): Mus musculus 
2012-01-31 | E-GEOD-35262 | biostudies-arrayexpress
TranscriptomicsTime-dependent expression of transcripts in human skeletal muscle
Five consecutive skeletal muscle biopsies were taken from a young healthy male research volunteer under controlled living conditions consisting of 3 meals and normal sleeping time. Samples were obtained with five hour-intervals, always at least 4 hours after the last meal at 8AM, 1PM, 6PM, 11PM and ...
ORGANISM(S): Homo sapiens 
2016-07-21 | E-GEOD-79934 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse adipocytes after telmisartan, pioglitazone or irbesartan treatment
expression pattern of adipocytes after telmisartan, pioglitazone or irbesartan treatment
ORGANISM(S): Mus musculus 
2008-06-12 | E-GEOD-2486 | biostudies-arrayexpress
TranscriptomicsWBERRABAH
Effect of variation of glucose concentration in FXR target genes expression in liver
ORGANISM(S): Homo sapiens 
2013-12-12 | E-MTAB-1743 | biostudies-arrayexpress
Transcriptomicsp16INK4a-deficiency promotes macrophages from classical to alternative activation
murine p16ink4a deficient (p16ko) and control (p16wt) bone marrow cells were either differentiated with normal LCM-supplemented differentiation medium to obtain bone marrow derived macrophages (BMDM) or supplemented with Interleukin 4 during differeniation to obtain M2 polarized p16wt and p16ko BMDM...
ORGANISM(S): Mus musculus 
2011-07-01 | E-MEXP-3216 | biostudies-arrayexpress
TranscriptomicsHepatic glucose sensing is required to preserve beta-cell glucose competence
We assessed the impact of glucose transporter Glut2 gene inactivation in adult mouse liver (LG2KO mice). This suppressed hepatic glucose uptake but not glucose output. In the fasted state, expression of carbohydrate responsive element-binding protein (ChREBP) and its glycolytic and lipogenic target ...
ORGANISM(S): Mus musculus 
2013-01-18 | E-GEOD-43581 | biostudies-arrayexpress
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