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TranscriptomicsIdentification of differentially expressed transcripts and pathways one week and six months following implant of left ventricular devices
A specific set of genes involved in regulating cellular immune response, antigen presentation, and T cell activation and survival were down-regulated 7 days after LVAD placement. 6 months following LVAD placement, the expression levels of these genes were significantly increased; yet importantly, re...
ORGANISM(S): Homo sapiens 
2013-05-06 | E-GEOD-46665 | biostudies-arrayexpress
TranscriptomicsSmooth muscle specific deletion of N-deacetylase-N-sulfotransferase 1 (Ndst1) results in increased arterial elasticity in mice
The hypothesis tested was that loss of Ndst1 in smooth muscle would lead to significant changes in gene expression and alter functional properties in large and small vessels. The increase in aortic elasticity was increased in mice lacking Ndst1 was associated with significant changes in genes that m...
ORGANISM(S): Mus musculus 
2013-02-16 | E-GEOD-44345 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq Reveals Unique Vascular Smooth Muscle Cell Phenotypes in Culture
Background. Heterogeneity in vascular smooth muscle cells (VSMCs) has been classically defined with a small set of predefined markers. Single cell genomics provides a unique unbiased approach to evaluate VSMC phenotypes. Objectives. The goal of this study was to define the heterogeneity of primary...
ORGANISM(S): Mus musculus 
2016-03-22 | E-GEOD-79436 | biostudies-arrayexpress
TranscriptomicsEvaluation of a New High-Dimensional miRNA Profiling Platform
We evaluated a new miRNA profiling platform that utilizes Illumina’s existing robust DASL chemistry as the basis for the assay. Using total RNA from five colon cancer patients and four cell lines, we evaluated the reproducibility of miRNA expression levels across replicates and with varying amoun...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17346 | biostudies-arrayexpress
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