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Transcriptomicsp53 Contributes to Differentiating Gene Expression Following Exposure to Acetaminophen and Its Less Hepatotoxic Regioisomer Both In Vitro and In Vivo
The goal of the present study was to compare hepatic toxicogenomic signatures across in vitro and in vivo mouse models following exposure to acetaminophen (APAP) or its relatively nontoxic regioisomer 3'-hydroxyacetanilide (AMAP). Two different Affymetrix microarray platforms and one Agilent Oligonu...
ORGANISM(S): Mus musculus 
2016-03-29 | E-GEOD-56576 | biostudies-arrayexpress
TranscriptomicsDifferential Regulation of Mitogen-Activated Protein Kinases by Acetaminophen in TAMH cells
Acetaminophen (APAP), a widely used analgesic and antipyretic that is considered to be relatively safe at recommended doses, is the leading cause of drug-induced liver failure in the United States. 3M-bM-^@M-^Y-Hydroxyacetanilide (AMAP), a regioisomer of acetaminophen is useful as a comparative too...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18614 | biostudies-arrayexpress
TranscriptomicsCalvarial osteoblast transcriptome analysis identifies genetic targets and extracellular matrix-mediated focal adhesion as potential biomarkers for single-suture craniosynostosis
Craniosynostosis is a disease defined by premature fusion of one or more cranial sutures. The mechanistic pathology of isolated single-suture craniosynostosis is complex and while a number of genetic biomarkers and environmental predispositions have been identified, in many cases the causes remain c...
ORGANISM(S): Homo sapiens 
2012-03-04 | E-GEOD-27976 | biostudies-arrayexpress
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