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TranscriptomicsHistone H3 acetylation of miRNA genes in HMEC and HMF
Normal cell type specific histone H3 acetylation of miRNA genes. HMEC and HMF represent two distinct differentiated cell type present in mammary gland each with a distinct phenotype, a distinct epigenotype as well as distinct miRNA expression pattern. The aim of the study was to determine how epigen...
ORGANISM(S): Homo sapiens 
2011-04-05 | E-GEOD-28375 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of different stages of human mammary epithelial cells from pre-statis to cancer
To characterize early epigenetic events in breast carcinogenesis, we analyzed DNA methylation state of different stages of HMECs from pre-stasis to cancer cell lines using human promoter microarray
ORGANISM(S): Homo sapiens 
2009-01-01 | E-MEXP-1889 | biostudies-arrayexpress
TranscriptomicsTranscriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles part 1
To further study the transcriptome of human mammary epithelial cells (HMEC 184) after exposure to polymeric Eudragit RS nanoparticles (ENP), we investigate whole genome microarray expression to identify genes regulated by exposure or not to ENP. Changes in gene expression in HMEC 184 cells (50M-BM- ...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45598 | biostudies-arrayexpress
TranscriptomicsTranscriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles part 2
To further study the transcriptome of human mammary epithelial cells (HMEC 184) after exposure to polymeric Eudragit RS nanoparticles (ENP), we investigate whole genome microarray expression to identify genes regulated by exposure or not to ENP. Changes in gene expression in HMEC 184 cells (90M-BM- ...
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45868 | biostudies-arrayexpress
TranscriptomicsExpression data of pre-stasis cultured HMEC
We have generated a large collection of normal human mammary epithelial cell strains from women aged 16 to 91 years, derived from primary tissues, to enable functional and molecular interrogation of aging. We demonstrate in finite-lifespan cultured and uncultured epithelial cells that aging is assoc...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37485 | biostudies-arrayexpress
TranscriptomicsDNA methylation of mortal and immortal breast cells
DNA methylation changes during immortalization of breast cells. The aim of the study was to determine whether differential epigentic state of TERT gene is involved in immortalization of breast cells. comparison of Pre-Stasis, Post-Selection, and immortal cells
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-48447 | biostudies-arrayexpress
TranscriptomicsAberrant DNA methylation of miRNA genes in breast cancer
Aberrant DNA methylation is frequently observed in cancer. The aim of the study was to determine how is DNA methylation of miRNA genes changed in breast cancer cell lines an breast tumor specimens. Breast cancer cell lines vs. HMEC. Breast tumor tissue specimens vs. non-tumor tissue specimens. Biol...
ORGANISM(S): Homo sapiens 
2012-05-25 | E-GEOD-38254 | biostudies-arrayexpress
TranscriptomicsTranscriptome study of human mammary epithelial cells following exposure to polymeric Eudragit RS nanoparticles
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-08-01 | E-GEOD-45869 | biostudies-arrayexpress
TranscriptomicsDNA methylation of miRNA genes in HMEC and HMF
Normal cell type specific DNA methylation of miRNA genes. HMEC and HMF represent two distinct differentiated cell type present in mammary gland each with a distinct phenotype, a distinct epigenotype as well as distinct miRNA expression pattern. The aim of the study was to determine how epigenetic mo...
ORGANISM(S): Homo sapiens 
2011-04-05 | E-GEOD-28374 | biostudies-arrayexpress
TranscriptomicsH3K4me3 in mortal and immortal breast cells
H3K4me3 changes during immortalization of breast cells. The aim of the study was to determine whether differential epigentic state of TERT gene is involved in immortalization of breast cells. comparison of Pre-Stasis, Post-Selection, and immortal cells
ORGANISM(S): Homo sapiens 
2013-07-03 | E-GEOD-48457 | biostudies-arrayexpress
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