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MetabolomicsSoftware tool for internal standard based normalization of lipids, and effect of data-processing strategies on resulting values

BACKGROUND: Lipidomics, the comprehensive measurement of lipids within a biological system or substrate, is an emerging field with significant potential for improving clinical diagnosis and our understanding of health and disease. While lipids diverse biological roles contribute ...

2022-05-17 | MTBLS710 | MetaboLights
MetabolomicsLimited oxygen availability in standard cell culture alters metabolism and function in terminally differentiated cells

Cell culture is generally considered to be hyperoxic. However, the importance of cellular oxygen consumption is often underappreciated, with rates of oxygen consumption often sufficient to cause hypoxia at cell monolayers. We initially focused on cultured adipocytes as a terminally differentiated...

2024-02-21 | MTBLS6677 | MetaboLights
MetabolomicsMetaboKit: a comprehensive data extraction tool for untargeted metabolomics (Standard mixture assay)

We have developed MetaboKit, a comprehensive software package for compound identification and relative quantification in mass spectrometry-based untargeted metabolomics analysis. In data dependent acquisition (DDA) analysis, MetaboKit constructs a customized spectral library with compound identit...

2021-11-05 | MTBLS1311 | MetaboLights
MetabolomicsLC–MS-Based Metabolomics Discriminates Premium from Standard Chilean cv. Cabernet Sauvignon Wines from Different Valleys

Cabernet Sauvignon grapes in Chile, mainly grown between the 30 °S and 36 °S, account for more than 30% of Chilean wine production, and yield wines with different characteristics which influence their quality. The aim of this study was to apply an LC-MS based metabolomic protocol to investigate t...

2022-01-28 | MTBLS2413 | MetaboLights
MetabolomicsUntargeted metabolomics of long-term drug intervention under standard diet in mice associated with lifespan

This study investigates urinary metabolic differences in young mice, aged mice, and aged mice supplemented with long-term drug intervention under standard diet. Untargeted metabolomics was performed using UHPLC-MS/MS in both positive (POS) and negative (NEG) ionization modes. The dataset provides...

2026-05-07 | MTBLS12889 | MetaboLights
MetabolomicsLipidCreator workbench to probe the lipidomic landscape - Targeted lipidomics analysis of Human Plasma samples and comparison with NIST SRM 1950 standard

Here we present LipidCreator, a software that fully supports targeted lipidomics assay development. LipidCreator offers a comprehensive framework to compute MS/MS fragment masses for over 60 lipid classes. LipidCreator provides all functionalities needed to define fragments, manage stable isotope...

2020-04-15 | MTBLS1375 | MetaboLights
MetabolomicsAbsolute quantification of metabolites in tomato fruit extracts by fast 2D NMR (Calibration Standard 700 MHz samples)

Quantitative NMR metabolomics is a powerful tool to have access to valuable information on metabolism. Unfortunately, the quantitative analysis of metabolic samples is often hampered by peak overlap. Two-dimensional (2D) spectroscopy offers a promising alternative and quantitative results can be ...

2015-11-11 | MTBLS134 | MetaboLights
MetabolomicsAbsolute quantification of metabolites in tomato fruit extracts by fast 2D NMR (Calibration Standard 500 MHz samples)

Quantitative NMR metabolomics is a powerful tool to have access to valuable information on metabolism. Unfortunately, the quantitative analysis of metabolic samples is often hampered by peak overlap. Two-dimensional (2D) spectroscopy offers a promising alternative and quantitative results can be ...

2015-11-11 | MTBLS133 | MetaboLights
GenomicsA somatic reference standard for cancer genome sequencing with COLO829
Identification of somatic alterations in cancer has become feasible with the massive adoption of next generation sequencing. However, due to variability in sequencing and informatics pipelines, a common somatic reference is needed. We thus performed paired whole genome sequencing of a metastatic mel...
EGAS00001001385 | EGA
GenomicsSorghum bicolor strain:Standard Yellow Milo | cultivar:Standard Yellow Milo
Sorghum bicolor strain:Standard Yellow Milo | cultivar:Standard Yellow Milo Genome sequencing
PRJNA331663 | ENA
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