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GenomicsA cell-permeable stapled peptide inhibitor of the estrogen receptor/coactivator interaction
A cell-permeable stapled peptide inhibitor of the estrogen receptor/coactivator interaction
PRJNA423076 | ENA
GenomicsSuppression of p53 response by blocking p53-Mediator binding with a stapled peptide
Suppression of p53 response by blocking p53-Mediator binding with a stapled peptide
PRJNA796059 | ENA
GenomicsSuppression of p53 response by blocking p53–Mediator binding with a stapled peptide
Suppression of p53 response by blocking p53–Mediator binding with a stapled peptide
PRJNA560381 | ENA
TranscriptomicsA cell-permeable stapled peptide inhibitor of the estrogen receptor/coactivator interaction
We and others have proposed that coactivator binding inhibitors, which block the interaction of estrogen receptor and steroid receptor coactivators, may represent a potential class of new breast cancer therapeutics. The development of coactivator binding inhibitors has been limited, however, because...
ORGANISM(S): Homo sapiens 
2018-01-09 | GSE108308 | GEO
TranscriptomicsStapled peptide inhibitors of RAB25 target context-specific phenotypes in cancer
The Ras-family small GTPase RAB25 is involved in numerous aspects of endosomal protein trafficking and cell polarity. Recent evidence has established a role for RAB25, as well as related RAB-family and effector proteins, in oncogenic signaling, highlighting the need for chemical probes targeting thi...
ORGANISM(S): Homo sapiens 
2017-07-18 | GSE101528 | GEO
UnknownComputational design of stapled peptide inhibitor against SARS-CoV-2 receptor binding domain.
Not available
S-EPMC9088457 | biostudies-literature
TranscriptomicsSuppression of p53 response by blocking p53–Mediator binding with a stapled peptide
DNA-binding transcription factors (TFs) have been challenging to target with molecular probes. Many TFs function in part through interaction with Mediator; we sought to block p53 function by disrupting the p53-Mediator interaction. Through rational design and activity-based screening, we characteriz...
ORGANISM(S): Homo sapiens 
2020-08-01 | GSE135870 | GEO
GenomicsSuppression of p53 response by blocking p53-Mediator binding with a stapled peptide
DNA-binding transcription factors (TFs) have been challenging to target with molecular probes. Many TFs function in part through interaction with Mediator; we sought to block p53 function by disrupting the p53-Mediator interaction. Through rational design and activity-based screening, we characteriz...
ORGANISM(S): Homo sapiens 
2022-04-05 | GSE193418 | GEO
UnknownHydrocarbon-Stapled Peptide Based-Nanoparticles for siRNA Delivery.
Not available
S-EPMC7760004 | biostudies-literature
UnknownStructure of a stapled peptide antagonist bound to nutlin-resistant Mdm2.
Not available
S-EPMC4130638 | biostudies-literature
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