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TranscriptomicsCharacterization of the melanoma miRNAome by deep sequencing
MicroRNAs are 18-23 nucleotide non-coding RNAs that regulate gene expression in a sequence specific manner. Little is known about the repertoire and function of miRNAs in melanoma or the melanocytic lineage. We therefore undertook a comprehensive analysis of the miRNAome in a diverse range of pigmen...
ORGANISM(S): Homo sapiens 
2010-03-22 | E-GEOD-18381 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of Melanoma Cell lines and Normal Melanocytes
To identify microRNAs potentially involved in melanomagenesis we compared microRNA transcription profiles between melanoma cell lines and cultured melanocytes. miRNA microarrays were manufactured by Agilent Technologies (Santa Clara, CA), and contain 20-40 features targeting each of 470 human miRNAs...
ORGANISM(S): Homo sapiens 
2011-10-16 | E-GEOD-25653 | biostudies-arrayexpress
UnknownImmunometabolic chaos in septic shock.
Not available
S-EPMC11879763 | biostudies-literature
GenomicsEGAS00001000017-sc-20110505 - samples
Familial Melanoma Sequencing
EGAD00001000016 | EGA
GenomicsFamilial Melanoma Sequencing
In this experiment we have sequenced the exome of 15 individuals from eight families who have familial melanoma. By sequencing the exome we hope to be able to identify new genes that are associated with this disease.
EGAS00001000017 | EGA
TranscriptomicsmicroRNA expression profiling and its integration with mRNA in metastatic melanoma reveal associations with BRAF mutation status and patient prognosis
Objectives/experimental design Samples eligible for this study (n=84) were obtained from lymph node specimens (Melanoma Institute Australia (MIA) Biospecimen Bank) in which macroscopic tumor was observed, obtained from patients believed to be without distant metastases at the time of tumor banking b...
ORGANISM(S): Homo sapiens 
2014-10-06 | E-GEOD-59334 | biostudies-arrayexpress
GenomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma

We conducted whole-genome sequencing of probands from several melanoma families, identifying one individual carrying a novel germline variant (c.G1075A, NM_000248.3; p.E318K, NP_000239.1; rs149617956) in the melanoma lineage-specific oncogene MITF. While the variant cosegregated with melanoma in ...

phs000419.v1.p1 | EGA
TranscriptomicsA novel recurrent mutation in MITF predisposes to familial and sporadic melanoma
We identified a novel germline mutation of the microphthalmia-associated transcription factor (MITF - E318K). This mutation was found to be present in numerous melanoma families, as well as the general population, where its association with melanoma has a significant effect. We determined the effe...
ORGANISM(S): Homo sapiens 
2011-12-01 | E-GEOD-31269 | biostudies-arrayexpress
UnknownThe National Lung Screening Trial: overview and study design.
Not available
S-EPMC3009383 | biostudies-literature
UnknownReconstructing evolutionary trajectories of mutation signature activities in cancer using TrackSig.
Not available
S-EPMC7002414 | biostudies-literature
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