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GenomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-40129 | biostudies-arrayexpress
GenomicsThe androgen receptor induces a distinct transcriptional program in castration resistant prostate cancer in man
The androgen receptor (AR) is the major transcriptional driver of prostate cell growth in man. For the first time, we define AR targets in prostate cancer (PC) tissue representing progression from treatment-naive to castrate-resistant disease (CRPC). We employed chromatin immunoprecipitation with hi...
ORGANISM(S): Homo sapiens 
2013-01-04 | E-GEOD-28219 | biostudies-arrayexpress
GenomicsNuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer [ChIP-seq]
Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. HIF1A is a major regulator of this process but activation of HIF1A under normoxic conditions,...
ORGANISM(S): Homo sapiens 
2014-11-26 | E-GEOD-55615 | biostudies-arrayexpress
TranscriptomicsGene expression in benign and prostate cancer tissue
Benign prostate tissue and prostate cancer tissue (untreated, androgen deprivation therapy responding, or castrate-resistant) was collected from patients at the time of transurethral resection of the prostate surgery. 24 samples, technical replicates.
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-28680 | biostudies-arrayexpress
Transcriptomics5-hydroxymethylcytosine marks promoters in colon that resist hypermethylation in cancer [Methylation27 Array]
The discovery of cytosine hydroxymethylation (5-hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behavior in colon cancer. 5-hmC is globally reduced in proliferating cells such as colon tumors and the gut crypt progenitors, fro...
ORGANISM(S): Homo sapiens 
2015-02-03 | E-GEOD-47071 | biostudies-arrayexpress
Transcriptomics5-hydroxymethylcytosine marks promoters in colon that resist hypermethylation in cancer [ExpressionArray]
The discovery of cytosine hydroxymethylation (5-hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behavior in colon cancer. 5-hmC is globally reduced in proliferating cells such as colon tumors and the gut crypt progenitors, fro...
ORGANISM(S): Homo sapiens 
2015-02-03 | E-GEOD-47063 | biostudies-arrayexpress
Genomics5-hydroxymethylcytosine marks promoters in colon that resist hypermethylation in cancer [seq]
The discovery of cytosine hydroxymethylation (5-hmC) as a mechanism that potentially controls DNA methylation changes typical of neoplasia prompted us to investigate its behavior in colon cancer. 5-hmC is globally reduced in proliferating cells such as colon tumors and the gut crypt progenitors, fro...
ORGANISM(S): Homo sapiens 
2015-02-03 | E-GEOD-47590 | biostudies-arrayexpress
UnknownEmergency Nurses' Perceived Barriers and Solutions to Engaging Patients With Life-Limiting Illnesses in Serious Illness Conversations: A United States Multicenter Mixed-Method Analysis.
Not available
S-EPMC10939973 | biostudies-literature
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