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GenomicsSTAT1 transcription factor in Human HeLa S3
We report the results of chromatin immunoprecipitation following by high-thoughput tag sequencing (ChIP-Seq) using the GA II platform from Illumina for the human transcription factor STAT1 in HeLa S3 cells. The STAT1 ChIP was performed using HeLa S3 cells that are stimulated using gamma-interferon. ...
ORGANISM(S): Homo sapiens 
2008-09-15 | E-GEOD-12782 | biostudies-arrayexpress
ModelsRateitschak2012 - Interferon-gamma (IFNγ) induced STAT1 signalling (PC_IFNg100)
Rateitschak2012 - Interferon-gamma (IFNγ) induced STAT1 signalling (PC_IFNg100) This model is described in the article: Parameter identifiability and sensitivity analysis predict targets for enhancement of STAT1 activity in pancreatic cancer and stellate cells. Rateitschak K, Wi...
2024-09-02 | BIOMD0000000585 | BioModels
TranscriptomicsGene expression in human endometrial cancer tissues and serous papillary endometrial cancer cell line, SPAC-1L, treated by STAT1-siRNA and/or IFN-gamma
Endometrial cancer is one of the most common gynecologic malignancies, and patients with high grade disease, especially serous papillary subtype (SPEC) are often related to the poor outcomes. Recent genome-wide analyses have revealed that SPEC exhibits gene expression profiles that are distinct from...
ORGANISM(S): Homo sapiens 
2014-03-20 | E-GEOD-56026 | biostudies-arrayexpress
Proteomicsin vitro kinase assays Identified of STAT1 phosphorylation sites-mediated LATS2
LATS1/2 are frequently down-regulated or mutated in endometrial cancer (EC), yet their exact role in endometrial tumor progression remains unclear. In this study, we unexpectedly discovered a new function of LATS1/2 in regulating MHC class I expression in EC. Knockout of LATS1/2 in EC cells led to s...
ORGANISM(S): Homo sapiens (Human) 
2024-06-16 | PXD043500 | Pride
In vitro phosphorylation Stat1 Lats2 
ProteomicsNovel non-canonical role of STAT1 in Natural Killer cell cytotoxicity
STAT1 is an important regulator of NK cell maturation and cytotoxicity. Although the consequences of Stat1-deficiency have been described in detail the underlying molecular functions of STAT1 in NK cells are only partially understood. Here we describe a novel non-canonical role of STAT1 that was unm...
ORGANISM(S): Mus musculus (Mouse) 
2016-10-07 | PXD002206 | Pride
Immunological synapse Vesicle F-actin Proteome Interactome 
TranscriptomicsSTAT1 independent control of a neurotropic measles virus challenge in primary neurons and infected mice
The objective of this study was to compare the ability of mice that lack STAT1 to resolve a neurotropic viral challenge, and to assess the ability of neurons obtained from these mice to be effectively cleared of virus by interferon gamma For the array, primary neurons were isolated from embryonic mi...
ORGANISM(S): Mus musculus 
2012-03-14 | E-GEOD-33057 | biostudies-arrayexpress
TranscriptomicsAbnormal Mammary Development in STAT1-null Mice is Stroma-Dependent
Stat1-null mice (129S6/SvEvTac-Stat1tm1Rds homozygous) uniquely develop estrogen-receptor-positive mammary tumors with incomplete penetrance and long latency. We studied the growth and development of the mammary glands in Stat1-null mice. Stat1-null MGs have faulty branching morphogenesis with abnor...
ORGANISM(S): Mus musculus 
2015-05-01 | E-GEOD-63025 | biostudies-arrayexpress
ModelsBegitt2014 - STAT1 cooperative DNA binding - double GAS polymer model
Begitt2014 - STAT1 cooperative DNA binding - double GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and modelling approaches. The authors have developed two ODE models to describe STAT1...
2024-09-02 | BIOMD0000000501 | BioModels
ModelsBegitt2014 - STAT1 cooperative DNA binding - single GAS polymer model
Begitt2014 - STAT1 cooperative DNA binding - single GAS polymer model The importance of STAT1-cooperative DNA binding in type 1 and type 2 interferon signalling has been studies using experimental and modelling approaches. The authors have developed two ODE models to describe STAT1...
2024-09-02 | BIOMD0000000500 | BioModels
Manuscript Accepted 
ProteomicsIdentifying interactors of IRF1 and STAT1 during type I and type II interferon treatment using proximity-dependent labeling
Identifying interactors of IRF1 and STAT1 in bone marrow-derived macrophages during type I and type II interferon treatment using the proximity-dependent labeling approach TurboID followed by Mass Spectrometry
ORGANISM(S): Mus musculus (Mouse) 
2024-03-12 | PXD040337 | Pride
Turboid Interactors Irf1 Ifn-ii Ifn-i Stat1 
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