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ProteomicsSuper-paramagnetic iron oxide nanoparticles reprogram the tumor microenvironment and reduce lung cancer growth
Tumor associated macrophages (TAMs) are known to play a role in a multitude of processes that facilitate lung cancer growth, including the suppression of tumoricidal immune activation and the absorption of chemotherapeutics. Therefore, deciphering new therapies to reprogram TAMs towards an anti-tumo...
ORGANISM(S): Mus musculus (Mouse) 
2024-04-18 | PXD040145 | Pride
Macrophages Immunotherapy Spion Iron Lung cancer 
ProteomicsInterleukin 13 disrupts type 2 pneumocyte stem cell activity
Chronic lung disease is increasing in prevalence and there is urgent need to advance our understanding of human lung biology in order to improve diagnosis and current treatments. The Th2 inflammatory cytokine Interleukin 13 (IL13) has been associated with both obstructive and fibrotic lung diseases...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2020-06-05 | PXD013006 | Pride
Idiopathic pulmonary fibrosis Secretome Alveolar epithelial cell 
GenomicsComparative FAIRE-seq analysis reveals distinguishing features of the chromatin structure of ground state- and primed pluripotent cells
We utilized FAIRE-seq to identify accesible chromatin in mouse embryonic-, epiblast-, and neural- stem cells in addition to mouse embryonic fibroblasts. Analysis of these data sets reveal cell type specific chromatin signatures that differentiate naïve and primed pluripotency. Functional analysis of...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-58520 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiling of human neural progenitor cells and neurons with DISC1 interruption
Purpose: Genetic and clinical association studies have identified disrupted-in-schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family, in which the translocation predisposes to psychiatric disorders. ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-71289 | biostudies-arrayexpress
TranscriptomicsAtypical DNA methylation of genes encoding cysteine-rich peptides in Arabidopsis thaliana
In plants, transposons and non-protein-coding repeats are epigenetically silenced by CG and non-CG methylation. This pattern of methylation is mediated in part by small RNAs and two specialized RNA polymerases, Pol IV and Pol V, in a process called RNA-directed DNA methylation. By contrast, many pr...
ORGANISM(S): Arabidopsis thaliana 
2012-11-22 | E-GEOD-34207 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
UnknownEffect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial.
Not available
S-EPMC8852295 | biostudies-literature
UnknownA deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.
Not available
S-EPMC7002586 | biostudies-literature
UnknownThe global, regional, and national burden of cancer, 1990-2023, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2023.
Not available
S-EPMC12687902 | biostudies-literature
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