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MetabolomicsOsmolality-based normalization enhances statistical discrimination of untargeted metabolomic urine analysis: results from a comparative study

INTRODUCTION: Because of its ease of collection, urine is one of the most commonly used matrices for metabolomics studies. However, unlike other biofluids, urine exhibits tremendous variability that can introduce confounding inconsistency during result interpretation. Despite man...

2023-09-04 | MTBLS1765 | MetaboLights
MetabolomicsUnraveling the Heterogeneity of Hyperuricemia Using Untargeted Metabolomics and Statistical Modeling

Background. Hyperuricemia is the second most prevalent metabolic disorder globally and exhibits pronounced heterogeneity in clinical practice. Only about 10% of individuals with asymptomatic hyperuricemia (HUA) progress to gout, yet the lack of specific biomarkers and precise therapeutic targets ...

2025-10-05 | MTBLS13094 | MetaboLights
MetabolomicsMultiomic Approach to Analyze Infant Gut Microbiota: Experimental and Analytical Method Optimization

BACKGROUND: The human intestinal microbiome plays a central role in overall health status, especially in early life stages. 16S rRNA amplicon sequencing is used to profile its taxonomic composition; however, multiomic approaches have been proposed as the most accurate methods for...

2021-08-18 | MTBLS2942 | MetaboLights
MetabolomicsA robust method for performing 1H-NMR lipidomics in embryonic zebrafish
The embryonic zebrafish is an ideal system for lipid analyses with relevance to many areas of bioscience research, including biomarkers and therapeutics. Research in this area has been hampered by difficulties in extracting, identifying and quantifying lipids. We employed 1H-NMR at 700MHz to profile...
2024-07-02 | MTBLS2396 | MetaboLights
MetabolomicsA new method for quantitative determination of bitter components of Belgian endive, with a focus on sesquiterpene oxalates
The sesquiterpene lactones typical of the genera Cichorium and Lactuca were historically thought to be present in the free and glycosylated form, but recent developments have highlighted the presence of highly unusual oxalyl esters. In this work, first a liquid chromatography method that requires mi...
2016-01-04 | MTBLS270 | MetaboLights
MetabolomicsAnalysis of the human adult urinary metabolome variations with age, body mass index and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses. ('Sacurine' data set)

Urine metabolomics is widely used for biomarker research in the fields of medicine and toxicology. As a consequence, characterization of the variations of the urine metabolome under basal conditions becomes critical in order to avoid confounding effects in cohort studies. Such physiological infor...

2017-01-20 | MTBLS404 | MetaboLights
MetabolomicsA statistical analysis of the effects of urease pre-treatment on the measurement of the urinary metabolome by gas chromatography–mass spectrometry
Urease pre-treatment of urine has been utilized since the early 1960s to remove high levels of urea from samples prior to further processing and analysis by gas chromatography–mass spectrometry (GC–MS). Aside from the obvious depletion or elimination of urea, the effect, if any, of urease pre-treatm...
2014-05-21 | MTBLS71 | MetaboLights
TranscriptomicsAssessing Statistical Significance in Microarray Experiments Using the Distance Between Microarrays
We propose a method to compare the location and variability of gene ex-pression between two groups of microarrays using a permutation test based on the pairwise distance between microarrays. The microarrays could be samples from distinct clinical or biological populations or microarrays prepared at ...
ORGANISM(S): Mus musculus 
2010-09-13 | E-GEOD-9424 | biostudies-arrayexpress
TranscriptomicsA comprehensive and universal method for assessing the performance of differential gene expression analyses
The number of methods for pre-processing and analysis of gene expression data continues to increase, often making it difficult to select the most appropriate approach. We present a simple procedure for the comparative estimation of a variety of methods for microarray data pre-processing and analysis...
ORGANISM(S): Homo sapiens 
2010-11-09 | E-GEOD-22630 | biostudies-arrayexpress
ProteomicsStatistical models for the analysis of isobaric Tags multiplexed quantitative proteomics
ABSTRACT: Mass spectrometry is being used to identify protein biomarkers that can facilitate development of drug treatment. Mass spectrometry based proteomics results in complex proteomic data that is hierarchical in nature often with small sample size studies. Generalized linear models (GLM) is th...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2017-07-28 | PXD005486 | Pride
Statistical models : proteomics Tmt Mixed models Biomarkers 
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