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TranscriptomicsSexually dimorphic characteristics of the small intestine and colon of prepubescent C57BL/6 mice
There is increasing appreciation for sexually dimorphic effects, but the molecular mechanisms underlying these effects are only partially understood. In the present study, we explored transcriptomics and epigenetic differences in the small intestine and colon of prepubescent male and female mice. In...
ORGANISM(S): Mus musculus 
2015-09-02 | E-GEOD-57516 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Colon data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39973 | biostudies-arrayexpress
TranscriptomicsStructural, functional and molecular analysis of the effects of aging in the small intestine and colon of C57BL/6J mice [Small Intestine data]
By regulating digestion and absorption of nutrients and providing a barrier against the external environment the intestine provides a crucial contribution to the maintenance of health. To what extent aging-related changes in the intestinal system contribute to the impaired health of the aging body i...
ORGANISM(S): Mus musculus 
2012-09-03 | E-GEOD-39974 | biostudies-arrayexpress
TranscriptomicsMaternal Western-style high fat diet induces sex-specific physiological and molecular changes in two-week-old mouse offspring
Maternal diet is associated with the development of metabolism-related and other non-communicable diseases in offspring. Underlying mechanisms, functional profiles, and molecular markers are only starting to be revealed. Here, we explored the physiological and molecular impact of maternal Western-st...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-46359 | biostudies-arrayexpress
TranscriptomicsAging-induced differential methylation in human PBMCs occurs with but often without change in expression of the associated gene (DNA Methylation)
Aging is a progressive process that results in the accumulation of intra- and extracellular alterations that in turn contribute to a reduction in health. Age-related changes in DNA methylation have been reported before and may be responsible for aging-induced changes in gene expression, although a c...
ORGANISM(S): Homo sapiens 
2014-05-09 | E-GEOD-49064 | biostudies-arrayexpress
TranscriptomicsMaternal exposure to a Western-style diet causes differences in microbiota composition and gene expression in the intestine of suckling mouse pups
During the last few decades, the long-lasting consequences of nutritional programming during the early phase of life have become increasingly evident, but the effects of maternal nutrition on the developing intestine are currently still relatively underexplored. In this study, we investigated in mic...
ORGANISM(S): Mus musculus 
2016-08-22 | E-GEOD-72705 | biostudies-arrayexpress
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